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SERPIND1 [extracellular region]
Stable Identifier
R-HSA-5578885
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Heparin cofactor 2, HEP2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
factor V -> factor Va + factor V activation peptide (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
SERPIND1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05546 SERPIND1
Gene Names
SERPIND1, HCF2
Chain
signal peptide:1-19, chain:20-499
Reference Genes
BioGPS Gene:3053 SERPIND1
COSMIC (genes):SERPIND1 SERPIND1
CTD Gene:3053 SERPIND1
dbSNP Gene:3053 SERPIND1
ENSEMBL:ENSG00000099937 SERPIND1
ENSEMBL:ENSG00000099937.11 SERPIND1
HGNC:4838 SERPIND1
KEGG Gene (Homo sapiens):3053 SERPIND1
Monarch:3053 SERPIND1
NCBI Gene:3053 SERPIND1
OMIM:142360 SERPIND1
UCSC:P05546 SERPIND1
Reference Transcript
RefSeq:NM_000185.3 SERPIND1
Other Identifiers
11727055_at
11727056_s_at
16927382
205576_PM_at
205576_at
3053
31825_at
3937744
3937745
3937746
3937747
3937748
3937750
3937751
8071420
A_14_P108995
A_23_P6335
A_24_P40306
A_33_P3241511
GE57991
GO:0004866
GO:0004867
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0006935
GO:0007596
GO:0007599
GO:0008201
GO:0010466
GO:0010951
GO:0030414
GO:0042060
GO:0043226
GO:0070062
GO:0098772
HMNXSV003029948
ILMN_1707975
M58600_rna1_at
PH_hs_0000198
TC22000072.hg
g7262380_3p_at
Participates
as an input of
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)
as a component of
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
Other forms of this molecule
p-SERPIND1 [endoplasmic reticulum lumen]
SERPIND1 [endoplasmic reticulum lumen]
Inferred To
HCII [extracellular region]
(Danio rerio)
Serpind1 [extracellular region]
(Mus musculus)
Serpind1 [extracellular region]
(Rattus norvegicus)
SERPIND1 [extracellular region]
(Bos taurus)
SERPIND1 [extracellular region]
(Canis familiaris)
SERPIND1 [extracellular region]
(Gallus gallus)
SERPIND1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_000176.2
OpenTargets
ENSG00000099937
HPA
ENSG00000099937-SERPIND1
GeneCards
P05546
Ensembl
ENST00000406799
,
ENST00000215727
,
ENSP00000384050
,
ENSG00000099937
,
ENSP00000215727
PRO
P05546
Pharos - Targets
P05546
HMDB Protein
HMDBP01712
PDB
1JMO
,
6KBV
,
6KBO
,
2NCW
,
6J12
,
1JMJ
,
2NCU
,
2NAT
,
2NCV
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