Reactome | RNA polymerase II polymerizes primary piRNA transcript

RNA polymerase II polymerizes primary piRNA transcript

Stable Identifier

R-HSA-5601926

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

piRNA locus is transcribed

ReviewStatus

5/5

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RNA polymerase II polymerizes primary piRNA transcript

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As inferred from experiments with mouse homologs, primary piRNA transcripts originate from multiple copy transposable elements and unique copy non-coding RNAs and mRNAs. As male germ cells progress from fetus to adult, the composition of piRNAs shifts from transposons to unique copy sequences (reviewed in Bortvin 2013). Computational analyses have identified 161 to 242 piRNA clusters and many other smaller piRNA hotspots in the mouse genome (Aravin et al. 2008, Rosenkranz and Zischler 2012, Jung et al. 2014). About 18% of pre-pachytene piRNAs in mouse originate from mRNAs encoding proteins (Aravin et al. 2008). Likewise 235 to 368 piRNA clusters were identified in the human genome (Rosenkranz and Zischler 2012, Gould et al. 2012, Yang et al. 2013, Jung et al. 2014).
As inferred from the mouse homolog, the MYBL1 (A-MYB) transcription factor drives transcription of both piRNA precursors and mRNAs encoding PIWI family proteins.

Literature References

PubMed ID	Title	Journal	Year
23056369	Selective constraint on copy number variation in human piwi-interacting RNA Loci Lukic, S, Chen, KC, Gould, DW	PLoS ONE	2012
23826142	MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing Yu, D, Hua, J, Ye, N, Zhang, Z, Shi, Q, Zhang, H, Zhang, Y, Cooke, HJ, Yang, Q, Wang, L, Xu, B	PLoS ONE	2013
22233380	proTRAC--a software for probabilistic piRNA cluster detection, visualization and analysis Zischler, H, Rosenkranz, D	BMC Bioinformatics	2012
24656595	piClust: A density based piRNA clustering algorithm Jung, I, Park, JC, Kim, S	Comput Biol Chem	2014
18922463	A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice Bourc'his, D, Toth, KF, Hannon, GJ, Bestor, T, Pezic, D, Aravin, AA, Sachidanandam, R, Schaefer, C	Mol. Cell	2008