TRAF3 R118W [cytosol]

Stable Identifier
R-HSA-5602321
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
TRAF3 R118W [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20832341 Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

Abel, L, Lebon, P, Bravo, J, Al-Muhsen, S, PĂ©rez de Diego, R, Herman, M, Chaix, Y, Lorenzo, L, Jouanguy, E, Warnatz, K, Plancoulaine, S, Vallabhapurapu, S, Puel, A, Picard, C, Bustamante, J, Zhang, SY, Cardon, A, Cascarrigny, F, Rozenberg, F, Durandy, A, Sancho-Shimizu, V, Casanova, JL, Karin, M, Tardieu, M

Immunity 2010
External Reference Information
External Reference
Gene Names
TRAF3, CAP1, CRAF1
Chain
chain:1-568
Other Identifiers
0000940739
11742091_a_at
11743501_a_at
11759502_at
16789080
208315_3p_x_at
208315_x_at
221571_at
3553338
3553346
3553358
3553359
3553363
3553364
3553367
3553368
3553370
3553374
3553382
3553383
3553384
3553386
3553388
37057_s_at
43952_at
7187
7977018
A_23_P37068
A_32_P89837
GE59008
GO:0001817
GO:0002224
GO:0002376
GO:0003674
GO:0004842
GO:0005164
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006464
GO:0006915
GO:0006950
GO:0007165
GO:0008063
GO:0008150
GO:0008219
GO:0008270
GO:0009058
GO:0009898
GO:0016579
GO:0016740
GO:0019899
GO:0019901
GO:0019903
GO:0030162
GO:0031410
GO:0031625
GO:0031996
GO:0032088
GO:0032648
GO:0032991
GO:0033209
GO:0034641
GO:0035631
GO:0035666
GO:0042802
GO:0042981
GO:0043122
GO:0043167
GO:0043226
GO:0045087
GO:0046330
GO:0046872
GO:0050688
GO:0070534
HMNXSV003033530
Hs.297660.1.S2_3p_at
ILMN_1793154
ILMN_2383774
PH_hs_0015383
PH_hs_0038599
TC14000786.hg
U15637_s_at
g4507678_3p_a_at
g4507678_3p_at
g4507678_3p_x_at
Participates
Other forms of this molecule
Modified Residues
Name
L-arginine 118 replaced with L-tryptophan
Coordinate
118
PsiMod
A protein modification that effectively converts a source amino acid residue to L-tryptophan.
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name Identifier Synonyms
primary immunodeficiency disease DOID:612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Interactors (42)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q99558 MAP3K14  5 0.887 9
 UniProt:Q92844 TANK  2 0.829 7
 UniProt:O43353 RIPK2  2 0.72 6
 UniProt:Q13546 RIPK1  13 0.703 5
 UniProt:Q9UHD2 TBK1  4 0.688 4
 UniProt:O95721 SNAP29  3 0.666 4
 UniProt:O00463 TRAF5      0.659 4
 UniProt:Q8TDR0 TRAF3IP1  2 0.639 8
 UniProt:P0DTC5 M  10 0.573 4
 UniProt:Q9HAV5 EDA2R  1 0.564 2
 UniProt:P36941 LTBR  1 0.564 2
 UniProt:Q5T681 CJ062      0.556 3
 UniProt:Q52MB2 CC184      0.556 3
 UniProt:Q8IYE1 CCD13      0.556 3
 UniProt:Q6ZSB9 ZBT49      0.556 3
 UniProt:Q8NAM6 ZSCA4      0.556 3
 UniProt:Q7KZS0 Q7KZS0      0.556 3
 UniProt:Q8N9N2-2 ASCC1      0.556 3
 UniProt:Q9UKD1 GMEB2      0.556 3
 UniProt:Q9Y547 HSPB11  2 0.556 3
 UniProt:O75928-2 PIAS2  1 0.556 3
 UniProt:Q16543 CDC37  1 0.556 3
 UniProt:Q13114 TRAF3  4 0.556 5
 UniProt:Q86UB2 BIVM      0.556 6
 UniProt:Q8TBB1 LNX1  1 0.556 3
 UniProt:Q0D2K3 RIPP1      0.556 3
 UniProt:P28062-2 PSMB8      0.556 3
 IntAct:EBI-22505066 CCSB ORF ID      0.556 3
 UniProt:P54725 RAD23A  1 0.556 3
 UniProt:Q17RL8 Q17RL8      0.556 3
 UniProt:P78317 RNF4  2 0.556 3
 UniProt:Q96HA1-2 POM121      0.556 3
 UniProt:Q96HA8 NTAQ1      0.556 3
 UniProt:Q96PC2 IP6K3  1 0.556 5
 UniProt:Q15628 TRADD  1 0.547 2
 UniProt:Q13490 BIRC2  5 0.527 3
 UniProt:P61964 WDR5  1 0.524 2
 UniProt:P25942 CD40      0.508 3
 UniProt:Q9Y692 GMEB1      0.508 2
 UniProt:Q9QYP6 AZI2      0.499 2
 UniProt:P15314  1 0.499 2
 UniProt:A2APF7 A2APF7      0.499 2
Cite Us!