Reactome | TRAF3 R118W [cytosol]

TRAF3 R118W [cytosol]

Stable Identifier

R-HSA-5602321

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser for interactor UniProt:Q13011 ECH1

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Literature References

PubMed ID	Title	Journal	Year
20832341	Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis Abel, L, Lebon, P, Bravo, J, Al-Muhsen, S, Pérez de Diego, R, Herman, M, Chaix, Y, Lorenzo, L, Jouanguy, E, Warnatz, K, Plancoulaine, S, Vallabhapurapu, S, Puel, A, Picard, C, Bustamante, J, Zhang, SY, Cardon, A, Cascarrigny, F, Rozenberg, F, Durandy, A, Sancho-Shimizu, V, Casanova, JL, Karin, M, Tardieu, M	Immunity	2010

External Reference Information

External Reference

UniProt:Q13114 TRAF3

Gene Names

TRAF3, CAP1, CRAF1, CAP-1, TRAFAMN

Chain

chain:1-568

Reference Genes

BioGPS Gene:7187 TRAF3

COSMIC (genes):CAP1 TRAF3

COSMIC (genes):TRAF3 TRAF3

CTD Gene:7187 TRAF3

dbSNP Gene:7187 TRAF3

ENSEMBL:ENSG00000131323 TRAF3

HGNC:12033 TRAF3

KEGG:hsa:7187 TRAF3

Monarch:7187 TRAF3

NCBI Gene:7187 TRAF3

OMIM:601896 TRAF3

UCSC:Q13114 TRAF3

Reference Transcript

Other Identifiers

11742091_a_at

11743501_a_at

11759502_at

16789080

208315_3p_x_at

208315_PM_x_at

208315_x_at

221571_PM_at

221571_at

3553338

3553346

3553358

3553359

3553360

3553361

3553363

3553364

3553365

3553367

3553368

3553370

3553373

3553374

3553378

3553379

3553380

3553381

3553382

3553383

3553384

3553386

3553388

37057_s_at

43952_at

7187

7977018

A_14_P118576

A_23_P37068

A_32_P89837

GE59008

GO:0000151

GO:0001817

GO:0002224

GO:0002376

GO:0003824

GO:0004842

GO:0005164

GO:0005515

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0006355

GO:0006915

GO:0007165

GO:0008063

GO:0008270

GO:0009898

GO:0010008

GO:0012501

GO:0016740

GO:0019899

GO:0019901

GO:0019903

GO:0030162

GO:0031410

GO:0031625

GO:0031996

GO:0032088

GO:0032481

GO:0032648

GO:0033209

GO:0034142

GO:0035631

GO:0035666

GO:0042802

GO:0042981

GO:0043122

GO:0043226

GO:0045087

GO:0046872

GO:0050688

GO:0051607

GO:0060337

GO:0061630

GO:0070534

GO:0098542

GO:0140096

GO:1902554

HMNXSV003033530

Hs.297660.1.S2_3p_at

ILMN_2383774

PH_hs_0015383

PH_hs_0038599

TC14000786.hg

TC14000789.hg

U15637_s_at

g4507678_3p_a_at

g4507678_3p_at

g4507678_3p_x_at

Participates

as an input of

Defective TRAF3 does not transmit the signal (Homo sapiens)

Other forms of this molecule

K63polyUb-TRAF3 [cytosol]

TRAF3 [cytosol]

K48polyUb-TRAF3 [cytosol]

Modified Residues

Name

L-arginine 118 replaced with L-tryptophan

Coordinate

118

PsiMod

L-tryptophan residue [MOD:00027]

A protein modification that effectively converts a source amino acid residue to L-tryptophan.

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

Disease

Name	Identifier	Synonyms
primary immunodeficiency disease	DOID:612	immune deficiency disorder, immunodeficiency syndrome, hypoimmunity

Cross References

RefSeq

XP_011535420.1, NP_663777.1, NP_663778.1, XP_016877106.1, XP_016877107.1, NP_001186356.1, NP_003291.2

OpenTargets

ENSG00000131323

ENSEMBL

ENSP00000445998, ENSP00000514678, ENST00000699894, ENSP00000454207, ENST00000392745, ENST00000539721, ENSP00000376500, ENST00000560371

HPA

ENSG00000131323-TRAF3

PRO

Q13114

Pharos - Targets

Q13114

GlyGen

Q13114

Orphanet

TRAF3

PDB

8T5P, 1KZZ, 1L0A, 2ECY, 1ZMS, 1RF3, 2GKW, 1FLL, 1FLK

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.918	10
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.87	8
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.742	6
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.72	6
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.703	5
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.688	4
UniProt:P41212 ETV6	14	ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912)	0.671	5
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.669	3
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.669	4
UniProt:O00463 TRAF5			0.659	4
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.639	8
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.573	4
UniProt:Q9UHJ6 SHPK	1	SHPK [cytosol] (R-HSA-8959710)	0.564	2
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	5
UniProt:Q17RL8 Q17RL8			0.556	3
IntAct:EBI-22505066 CCSB ORF ID			0.556	3
UniProt:Q0D2K3 RIPP1			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q86UB2 BIVM			0.556	6
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.556	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q9Y547 HSPB11	2	HSPB11 [ciliary tip] (R-HSA-5625342) HSPB11 [cilium] (R-HSA-5617628)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q9UKD1 GMEB2			0.556	3
UniProt:Q8N9N2-2 ASCC1			0.556	3
UniProt:Q8NAM6 ZSCAN4	1	ZSCAN4 [nucleoplasm] (R-HSA-9816447)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q5T681 CJ062			0.556	3
UniProt:Q52MB2 CC184			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q96HA1-2 POM121			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:P28062-2 PSMB8			0.556	3
UniProt:Q6ZSB9 ZBT49			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.547	2
UniProt:Q01844 EWS			0.547	2
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.527	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	3
UniProt:Q9UJT2 TSKS			0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.524	2
UniProt:P25942 CD40			0.508	3
UniProt:Q9Y692 GMEB1			0.508	2
UniProt:P15314	1	Irf1 [nucleoplasm] (R-MMU-983456)	0.499	2
UniProt:A2APF7 A2APF7			0.499	2
UniProt:Q9QYP6 AZI2			0.499	2

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