Reactome | MyD88 E65del [cytosol]

MyD88 E65del [cytosol]

Stable Identifier

R-HSA-5602598

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
23002119	IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients Alcais, A, Bonnet, M, Reynaud, CA, Weller, S, Camcioglu, Y, Roifman, C, Zitnik, SE, Cerutti, A, Hoarau, C, Israel, L, Vasconcelos, J, Weill, JC, Delagreverie, H, Rodrigo, C, Arkwright, PD, Chrabieh, M, Issekutz, AC, Rodriguez-Gallego, C, Garty, BZ, Puel, A, Picard, C, Meffre, E, Zhang, SY, Maródi, L, Casanova, JL	Blood	2012

External Reference Information

External Reference

UniProt:Q99836 MYD88

Gene Names

MYD88

Chain

chain:1-296

Reference Genes

BioGPS Gene:4615 MYD88

COSMIC (genes):MYD88 MYD88

CTD Gene:4615 MYD88

dbSNP Gene:4615 MYD88

ENSEMBL:ENSG00000172936 MYD88

HGNC:7562 MYD88

KEGG:hsa:4615 MYD88

Monarch:4615 MYD88

NCBI Gene:4615 MYD88

OMIM:602170 MYD88

UCSC:Q99836 MYD88

Reference Transcript

Participates

as a candidate of

MyD88 variants [cytosol] (Homo sapiens)

Other forms of this molecule

MYD88 [cytosol]

MYD88 [plasma membrane]

MYD88 [endosome membrane]

MyD88 S34Y [cytosol]

MyD88 L93P [cytosol]

MyD88 E52del [cytosol]

MyD88 R196C [cytosol]

Modified Residues

Name

Deletion of residues 65 to 65

Cross References

RefSeq

NP_001166037.1, NP_001166039.1, NP_001166040.1, NP_002459.2

OpenTargets

ENSG00000172936

ENSEMBL

ENSG00000172936, ENSP00000401399, ENSP00000391753, ENST00000650112, ENSP00000499012, ENSP00000497991, ENSP00000498360, ENST00000417037, ENST00000421516, ENST00000650905, ENST00000651800

GeneCards

MYD88

HPA

ENSG00000172936-MYD88

PRO

Q99836

Pharos - Targets

Q99836

GlyGen

Q99836

Orphanet

MYD88

PDB

4EO7, 8W8M, 7L6W, 2Z5V, 7BER, 7BEQ, 2JS7, 4DOM, 6I3N, 3MOP

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MYD88 [cytosol] (R-HSA-166059) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.958	40
UniProt:Q9NWZ3 IRAK4	9	IRAK4 [cytosol] (R-HSA-166081) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 E402* [cytosol] (R-HSA-5602517) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 Q293* [cytosol] (R-HSA-5602426)	0.922	15
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.861	9
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.837	8
UniProt:O00206 TLR4	2	2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045) TLR4 [endosome membrane] (R-HSA-2201285)	0.758	4
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-167992) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-9637646)	0.737	4
UniProt:P51617 IRAK1	14	IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [endosome membrane] (R-HSA-975127) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687)	0.723	4
UniProt:O14836 TNFRSF13B	1	TAC1 [plasma membrane] (R-HSA-5668752)	0.692	12
UniProt:Q6SZW1 SARM1			0.622	5
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.602	4
UniProt:Q8NF50 DOCK8	1	DOCK8 [cytosol] (R-HSA-1011619)	0.576	3
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.573	3
UniProt:Q6IQ16 SPOPL	1	SPOPL [nucleoplasm] (R-HSA-5635036)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q69FE3 Q69FE3			0.556	5
UniProt:P13682 ZNF35			0.556	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.543	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.543	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.543	3
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.524	6
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.524	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.462	8

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