TLR3 E746* [endosome membrane]

Stable Identifier
R-HSA-5602730
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Icon
TLR3 E746* [endosome membrane] icon
TLR3 E746* [endosome membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
21911422 Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

Abel, L, Doireau, V, Lebon, P, Lorenzo, L, Plancoulaine, S, Alsina, L, Cardon, A, Rozenberg, F, Sancho-Shimizu, V, Azevedo, J, Ciancanelli, M, Chaussabel, D, Geissmann, F, Philippe, PB, Pérez de Diego, R, Herman, M, Jouanguy, E, Vogt, G, Andrianirina, ZZ, Picard, C, Zhang, SY, Pauwels, E, Anguiano, E, Guo, Y, Audry, M, Casanova, JL, Tardieu, M

J. Exp. Med. 2011
External Reference Information
External Reference
UniProt:O15455 TLR3
Gene Names
TLR3
Chain
signal peptide:1-23, chain:24-904
Reference Genes
BioGPS Gene:7098 TLR3
COSMIC (genes):TLR3 TLR3
CTD Gene:7098 TLR3
dbSNP Gene:7098 TLR3
ENSEMBL:ENSG00000164342 TLR3
ENSEMBL_homo_sapiens_GENE:ENSG00000164342.14 TLR3
HGNC:11849 TLR3
KEGG Gene (Homo sapiens):7098 TLR3
Monarch:7098 TLR3
NCBI Gene:7098 TLR3
OMIM:603029 TLR3
UCSC:O15455 TLR3
Reference Transcript
Other Identifiers
11730296_a_at
16972993
206271_PM_at
206271_at
239587_PM_at
239587_at
242667_PM_at
242667_at
2754939
2754943
2754944
2754945
2754946
2754947
2754948
2754949
2754950
2754951
2754952
2754953
2754954
2754955
2754956
2754957
2754958
2754959
2754960
2754961
2754962
2754963
2754964
2754972
33488_at
7098
79848_at
80052_i_at
80054_r_at
8098611
A_23_P29922
A_32_P171793
A_32_P49054
GE476559
GE59525
GO:0000139
GO:0000165
GO:0001774
GO:0002224
GO:0002376
GO:0002730
GO:0003723
GO:0003725
GO:0004888
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006351
GO:0006355
GO:0006952
GO:0006954
GO:0006955
GO:0006972
GO:0007165
GO:0007250
GO:0007252
GO:0007254
GO:0008584
GO:0009597
GO:0009615
GO:0010008
GO:0010628
GO:0012501
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0030312
GO:0031012
GO:0031410
GO:0032481
GO:0032722
GO:0032727
GO:0032728
GO:0032729
GO:0032735
GO:0032755
GO:0032757
GO:0032760
GO:0034138
GO:0034343
GO:0034346
GO:0035458
GO:0036020
GO:0036211
GO:0038023
GO:0038187
GO:0042742
GO:0042802
GO:0043065
GO:0043123
GO:0043226
GO:0043330
GO:0043331
GO:0045087
GO:0045671
GO:0045766
GO:0045944
GO:0046330
GO:0048856
GO:0050729
GO:0051607
GO:0060089
GO:0060907
GO:0071260
GO:0071346
GO:0071360
GO:0071466
GO:0090594
GO:0097191
GO:0097527
GO:0098542
GO:0098586
GO:1900017
GO:1901224
HMNXSV003003562
Hs.145926.0.A1_3p_at
Hs.201600.0.A1_3p_at
ILMN_1689578
ILMN_2155708
PH_hs_0002558
TC04000912.hg
TC04002368.hg
g4507530_3p_at
Participates
as a member of
Other forms of this molecule
TLR3 P554S [endosome membrane]
TLR3 [endoplasmic reticulum membrane]
TLR3 [endolysosome membrane]
TLR3 [Golgi membrane]
TLR3 [endosome membrane]
Modified Residues
Name
Nonsense mutation at L-glutamic acid 746
Coordinate
746
PsiMod
L-glutamic acid removal [MOD:01636]
A protein modification that effectively removes or replaces an L-glutamic acid.
Disease
Name Identifier Synonyms
primary immunodeficiency disease DOID:612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O15455 TLR3  6 0.744 5
 UniProt:P27986 PIK3R1  16 0.524 2
 UniProt:P11226 MBL2  1 0.463 2
 UniProt:Q7L0X0 TRIL      0.463 2
 UniProt:P12931 SRC  6 0.463 2
Cite Us!