Reactome | NCOA1 (868-1441) [nucleoplasm]

NCOA1 (868-1441) [nucleoplasm]

Stable Identifier

R-HSA-5603230

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor coactivator 1 C-terminal fragment, NCOA1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15788 NCOA1

Gene Names

NCOA1, BHLHE74, SRC1

Chain

initiator methionine:, chain:2-1441

Reference Genes

BioGPS Gene:8648 NCOA1

COSMIC (genes):NCOA1 NCOA1

CTD Gene:8648 NCOA1

dbSNP Gene:8648 NCOA1

ENSEMBL:ENSG00000084676 NCOA1

HGNC:7668 NCOA1

KEGG:hsa:8648 NCOA1

Monarch:8648 NCOA1

NCBI Gene:8648 NCOA1

OMIM:602691 NCOA1

UCSC:Q15788 NCOA1

Reference Transcript

Other Identifiers

11721339_a_at

11721340_s_at

11721341_s_at

11721342_a_at

11721343_a_at

11728845_a_at

16877728

209105_PM_at

209105_at

209106_PM_at

209106_at

209107_PM_x_at

209107_x_at

210249_PM_s_at

210249_s_at

2473150

2473151

2473152

2473173

2473174

2473177

2473178

2473191

2473192

2473194

2473195

2473199

2473201

2473203

2473207

2473208

2473209

2473213

2473214

2473218

2473219

2473220

2473221

2473222

2473223

2473224

2473225

2473226

2473231

2473232

2473233

2473234

2473235

2473236

2473241

2473242

2473244

2473245

2473247

2473248

2473249

2473250

2473260

2473261

2473262

2473264

2473265

2473266

2473267

2473268

2473269

2473270

2473271

2473272

2473273

36118_at

484_at

65715_at

8040552

8648

89486_at

A_14_P128411

A_14_P131560

A_14_P133015

A_23_P39602

A_33_P3270009

GE55134

GE85573

GO:0000435

GO:0000785

GO:0000977

GO:0002155

GO:0003677

GO:0003682

GO:0003713

GO:0003824

GO:0004402

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0007595

GO:0008584

GO:0009725

GO:0016071

GO:0016740

GO:0016746

GO:0016922

GO:0021549

GO:0021766

GO:0021854

GO:0021987

GO:0022414

GO:0030331

GO:0030374

GO:0030520

GO:0032355

GO:0032526

GO:0032570

GO:0032870

GO:0032991

GO:0035357

GO:0042789

GO:0042974

GO:0043065

GO:0043226

GO:0044849

GO:0044877

GO:0045666

GO:0045893

GO:0045925

GO:0045944

GO:0046965

GO:0046983

GO:0048856

GO:0050847

GO:0060090

GO:0060179

GO:0060713

GO:0061629

GO:0061733

GO:0090575

GO:0140096

GO:0140110

GO:1900076

GO:1904017

GO:1904179

HMNXSV003017194

Hs.74002.0.S2_3p_at

Hs.74002.0.S3_3p_at

ILMN_1669033

ILMN_1785785

ILMN_2335198

PH_hs_0024380

TC02000137.hg

U59302_at

g726037_3p_a_at

Participates

as a component of

NCOA1(868-1441):PAX3(1-319) [nucleoplasm] (Homo sapiens)

as an input of

NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)

Other forms of this molecule

NCOA1 [nucleoplasm]

monoSUMO1-K732,K774-NCOA1 [nucleoplasm]

Inferred To

Ncoa1 [nucleoplasm] (Mus musculus)

Ncoa1 [nucleoplasm] (Rattus norvegicus)

NCOA1 [nucleoplasm] (Bos taurus)

NCOA1 [nucleoplasm] (Canis familiaris)

NCOA1 [nucleoplasm] (Gallus gallus)

NCOA1 [nucleoplasm] (Sus scrofa)

tai [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_671756.1, XP_016860658.1, XP_016860657.1, NP_003734.3, XP_005264682.1, XP_005264683.1, XP_005264685.1, NP_671766.1

Guide to Pharmacology - Targets

2693

ENSEMBL

ENST00000405141, ENSP00000320940, ENSP00000385097, ENST00000348332, ENSP00000379197, ENSP00000288599, ENST00000395856, ENSP00000385216, ENST00000288599, ENST00000406961

OpenTargets

ENSG00000084676

ZINC - Substances

NCOA1_HUMAN

ZINC target

Q15788

PRO

Q15788

GlyGen

Q15788

PDB

3P88, 5Q0K, 1ZAF, 7Y8F, 2FVJ, 3CWD, 1XIU, 5E7V, 6ITM, 5Q0P, 1K74, 8SVS, 3OLF, 2HBH, 7XWQ, 2GTK, 5AVL, 1X76, 3KMR, 6A5X, 5DSH, 4DQM, 6FOB, 7BNU, 3FUR, 5Q0O, 7BQ0, 3ET1, 5Q1D, 5Q0Z, 4TV1, 1XV9, 4UDA, 3OOF, 4MG6, 5Q1I, 5Q18, 6TFI, 3S9S, 6E3G, 6JNR, 6BNS, 2A3I, 4Y29, 6W9H, 8SVN, 4G1D, 3OMK, 3UUD, 4DK8, 5OW9, 4G1Z, 4TUZ, 1TFC, 6A5Y, 5Q1F, 5A86, 3CTB, 3DR1, 6L96, 3DCT, 1X7J, 3RUU, 2HCD, 5NKY, 5Q0W, 5Q1G, 2HC4, 5Q0L, 5Q1A, 5X8W, 7B39, 5MWP, 8SVP, 8SVX, 5AZT, 6ILQ, 7BPZ, 7BQ3, 6W9I, 5YP6, 4RUP, 8SVU, 5Q12, 4G1Y, 3OLL, 6KTM, 5DV6, 2P54, 7BNS, 5Q15, 7CXK, 7QPI, 6A5W, 6GEV, 3RUT, 8HUM, 2C52, 5L7G, 3FXV, 7WQQ, 6XP9, 6SSQ, 5AVI, 4J5X, 1NRL, 5Q1B, 3GYU, 7KXE, 7ZFX, 3G8I, 7XWP, 5Q13, 5DV8, 5Q0Q, 7BPY, 7BQ2, 4MGD, 6T2M, 7ZFG, 4DM8, 3VN2, 5OW7, 1X7B, 5NMB, 3OMP, 5DV3, 7XVZ, 3G9E, 7WGP, 9EYR, 7CXJ, 5Q0T, 2NPA, 6HTY, 1FM6, 5Q19, 5DWL, 8HUP, 3FEJ, 4MGC, 5X8U, 4HEE, 5Q1H, 7OXZ, 6IJS, 3FEI, 5Q0M, 5Q0R, 1RDT, 3HC6, 8SVO, 3OMO, 3UU7, 4JYI, 5YCN, 4DK7, 7KXD, 8HUK, 5OWD, 1X78, 3IPU, 4DM6, 6KTN, 3HC5, 7XWR, 5JI0, 5Q16, 1YYE, 4F9M, 3OKI, 6A5Z, 2NV7, 5Q0X, 8CKC, 1K7L, 9FBF, 4MGB, 3OMQ, 4JYH, 3HVL, 5NWM, 1KV6, 1U3R, 5Q14, 1N4H, 3OMM, 8SVR, 7XVY, 6FO9, 7BQ4, 5NMA, 3LMP, 4FGY, 4RUJ, 3GYT, 7CXL, 6U25, 8CK5, 3IPS, 7WGO, 3OKH, 7OY4, 5Q0U, 5Y44, 3H0A, 1XVP, 6ICJ, 7C6Q, 5Q0Y, 5YCP, 4MGA, 4MG9, 2HFP, 6L6K, 6JQ7, 5X0R, 6IJR, 1K4W, 5GTP, 7CXI, 1U3S, 5Q0S, 6FO7, 8SVQ, 6NX1, 3V9Y, 2PRG, 7KXF, 3UUA, 5MX7, 4G21, 6GG8, 6P9F, 5DVC, 5Q1E, 5L7H, 7YFK, 5GTN, 6A60, 1YY4, 3T03, 7CXF, 4MG8, 5L7E, 7BQ1, 7TRB, 3ET3, 5Q0N, 3QT0, 6FOD, 4UDB, 4JYG, 1FM9, 3P89, 5Q0J, 5JMM, 6FO8, 3OLS, 8HUQ, 1PZL, 5HJS, 8SVT, 5Q11, 3IPQ, 3RVF, 4G20, 5MWY, 7Y8G, 3BQD, 1P8D, 7BO6, 7WGQ, 7JYM, 7CXH, 3OOK, 5GTO, 3DCU, 5Q1C, 4MG5, 5Q10, 1NQ7, 3BEJ, 8F5Y, 5Q0V, 4MG7, 7AOS, 4G2H

HPA

ENSG00000084676-NCOA1

Pharos - Targets

Q15788

ZINC - Predictions - Purchasable

NCOA1_HUMAN

HMDB Protein

HMDBP00039

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.869	7
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.857	14
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.835	8
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.691	15
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.669	4
UniProt:P11473 VDR	2	VDR [nucleoplasm] (R-HSA-375512) polySUMO2-VDR [nucleoplasm] (R-HSA-4546376)	0.656	3
UniProt:P19785	13	ESR1 [cytosol] (R-MMU-9020968) ESR1 [nucleoplasm] (R-MMU-446168) Me87-PalmS-ER alpha36 [plasma membrane] (R-MMU-9637786) Me260-PalmS-ESR1 [plasma membrane] (R-MMU-9637788) PalmS-ER alpha36 [plasma membrane] (R-MMU-9021053) PalmS-ESR1 [plasma membrane] (R-MMU-9021057) PalmS-ER alpha46 [cytosol] (R-MMU-9020991) PalmS-ESR1 [cytosol] (R-MMU-9020974) Me260-ESR1 [cytosol] (R-MMU-9632177) phospho-p-S167-ESR1 [cytosol] (R-MMU-9841254) phospho-p-S167-ESR1 [nucleoplasm] (R-MMU-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-MMU-4090302) phospho-p-S118-ESR1 [nucleoplasm] (R-MMU-9024210)	0.646	3
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.625	4
taurochenodeoxycholic acid [ChEBI:16525]	2	taurochenodeoxycholate [peroxisomal matrix] (R-ALL-193484) TCDCA [cytosol] (R-ALL-159422)	0.623	2
UniProt:Q96RI1-2 NR1H4	2	SUMO1-K132,K289-NR1H4 [nucleoplasm] (R-HSA-4755487) NR1H4-2 [nucleoplasm] (R-HSA-3196161)	0.623	5
ChEBI:16755 CHENODEOXYCHOLIC ACID			0.623	2
ChEBI:36274 GLYCOCHENODEOXYCHOLIC ACID			0.623	2
UniProt:O75469 NR1I2			0.602	5
UniProt:Q63ZY3 KANK2			0.59	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.581	3
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628)	0.576	8
UniProt:Q96RI1 NR1H4	1	NR1H4 [nucleoplasm] (R-HSA-5340228)	0.558	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P59598	1	Asxl1 [nucleoplasm] (R-MMU-5689645)	0.544	2
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.524	4
UniProt:P06536	10	Nr3c1 [nucleoplasm] (R-RNO-3196163) Nr3c1 [nucleoplasm] (R-RNO-3196152) Nr3c1 [nucleoplasm] (R-RNO-3196155) Nr3c1 [nucleoplasm] (R-RNO-3196158) Nr3c1 [nucleoplasm] (R-RNO-3196159) Nr3c1 [nucleoplasm] (R-RNO-3196167) Nr3c1 [nucleoplasm] (R-RNO-3196173) Nr3c1 [nucleoplasm] (R-RNO-3196175) Nr3c1 [cytosol] (R-RNO-5618118) Nr3c1 [nucleoplasm] (R-RNO-4341106)	0.524	2
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.519	2
UniProt:P25799	8	Nfkb1 [secretory granule lumen] (R-MMU-6801004) Nfkb1 [extracellular region] (R-MMU-6806304) Nfkb1 [specific granule lumen] (R-MMU-6799557) Nfkb1 [cytosol] (R-MMU-168168) Nfkb1 [nucleoplasm] (R-MMU-177655) Nfkb1 [cytosol] (R-MMU-451607) phospho-Nfkb1 [cytosol] (R-MMU-451611) phospho-Nfkb1 [cytosol] (R-MMU-451619)	0.508	2
UniProt:PGR ENSG00000082175			0.499	2

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