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p100:RELB binds active NIK:p-IKKA dimer
Stable Identifier
R-HSA-5607720
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
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NFKB2 (also known as p100) is a member of the NF-kB family of transcription factors. It is synthesised as large precursor with an N-terminal RHD (Rel homology domain) and a C-terminal series of ankyrin repeats that masks the nuclear localization signal of NFKB2/p100 localising it to the cytosol. In resting cells, p100 is associated with RELB (Transcription factor RelB) in the cytosol. Upon cell stimulation, the IkB-like C terminus of p100 is proteolyzed, resulting in RELB-p52 dimers that translocate to the nucleus (Senftleben et al. 2001, Hayden & Ghosh 2004). IKKA (I kappa-B kinase alpha) does not associate directly with p100 but in the presence of NIK (NF-kB-inducing kinase), IKKA stably binds to p100. Serine residues 866 and 870 of p100 are essential for the recruitment of IKKA to p100 by NIK. This interaction is required for p100 phosphorylation and subsequent processing by IKKA (Xiao et al. 2001, 2004).
Literature References
PubMed ID
Title
Journal
Year
11239468
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
Sun, SC
,
Harhaj, EW
,
Xiao, G
Mol. Cell
2001
15140882
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
Fong, A
,
Sun, SC
,
Xiao, G
J. Biol. Chem.
2004
Participants
Input
Active NIK:p-S176,180-IKKA dimer [cytosol]
(Homo sapiens)
p100:RELB [cytosol]
(Homo sapiens)
Output
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol]
(Homo sapiens)
Participates
as an event of
NIK-->noncanonical NF-kB signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
Orthologous Events
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)
p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)
p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)
Authored
Garapati, P V (2014-07-14)
Reviewed
Geijtenbeek, TB (2014-09-02)
Created
Garapati, P V (2014-07-14)
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