Reactome | Active NIK phosphorylates IKKA dimer

Active NIK phosphorylates IKKA dimer

Stable Identifier

R-HSA-5607722

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - NIK-->noncanonical NF-kB signaling (Homo sapiens)
      - Active NIK phosphorylates IKKA dimer (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
        
        Active NIK phosphorylates IKKA dimer (Homo sapiens)

General

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Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B kinase alpha (IKKA) by directly phosphorylating the Ser176 and Ser180 with in the activation loop of IKKA. This phoshorylation is required for IKKA activity (Ling et al. 1998). Besides activating IKKA, NIK also serves as a docking molecule recruiting IKKA to p100 (Xiao et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
17047224	Regulation and function of IKK and IKK-related kinases Karin, M, Hacker, H	Sci STKE	2006
9520446	NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176 Ling, L, Goeddel, DV, Cao, Z	Proc Natl Acad Sci U S A	1998
11520989	Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway Karin, M, Krähn, G, Senftleben, U, Bonizzi, G, Fong, A, Sun, SC, Greten, FR, Hu, Y, Chen, Y, Xiao, G, Cao, Y	Science	2001