Active NIK phosphorylates IKKA dimer

Stable Identifier
R-HSA-5607722
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Active NIK phosphorylates IKKA dimer
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Accumulated NF-kB-inducing kinase (NIK) activates I kappa-B kinase alpha (IKKA) by directly phosphorylating the Ser176 and Ser180 with in the activation loop of IKKA. This phoshorylation is required for IKKA activity (Ling et al. 1998). Besides activating IKKA, NIK also serves as a docking molecule recruiting IKKA to p100 (Xiao et al. 2004).
Literature References
PubMed ID Title Journal Year
17047224 Regulation and function of IKK and IKK-related kinases

Hacker, H, Karin, M

Sci STKE 2006
9520446 NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

Ling, L, Cao, Z, Goeddel, DV

Proc Natl Acad Sci U S A 1998
11520989 Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

Senftleben, U, Cao, Y, Xiao, G, Greten, FR, Krähn, G, Bonizzi, G, Chen, Y, Hu, Y, Fong, A, Sun, SC, Karin, M

Science 2001
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Active NIK [cytosol]

Physical Entity
Active NIK [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Danio rerio)
Active NIK phosphorylates IKKA dimer (Gallus gallus)
Active NIK phosphorylates IKKA dimer (Mus musculus)
Active NIK phosphorylates IKKA dimer (Rattus norvegicus)
Active NIK phosphorylates IKKA dimer (Sus scrofa)
Active NIK phosphorylates IKKA dimer (Xenopus tropicalis)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)
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