Reactome | Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB

Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB

Stable Identifier

R-HSA-5607726

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB

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After being recruited into the NIK (NFkB-inducing kinase) complex, activated IKKA (I kappaB kinase alpha) phosphorylates serine residues 99, 108, 115, 123, 866, 870 and 872 located in both N- and C-terminal regions of NFKB2/p100. The phosphorylation of these specific serines is the prerequisite for ubiquitination and subsequent processing of p100. The C-terminal serine residues create a binding site for beta-TRCP (beta-transducinrepeat-containing protein), a ubiquitin E3 ligase (Xiao et al. 2001 & 2004, Liang et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
11239468	NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100 Sun, SC, Harhaj, EW, Xiao, G	Mol. Cell	2001
16303288	beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870 Liang, C, Sun, SC, Zhang, M	Cell. Signal.	2006
15140882	Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation Fong, A, Sun, SC, Xiao, G	J. Biol. Chem.	2004