PKC-delta is activated

Stable Identifier
R-HSA-5607746
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PKC-delta is activated
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Membrane-bound PKC adopts an open conformation, in which the pseudosubstrate is released from the kinase domain, allowing downstream signaling (Newton 2010).
Literature References
PubMed ID Title Journal Year
19934406 Protein kinase C: poised to signal

Newton, AC

Am. J. Physiol. Endocrinol. Metab. 2010
15105418 Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta

Cho, W, Rafter, JD, Digman, MA, Medkova, M, Stahelin, RV, Melowic, HR, Ananthanarayanan, B

J. Biol. Chem. 2004
Participants
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Output
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Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)
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