TAK1-binding protein 2 (TAB2), or its homologue TAB3, binds preferentially to K63-linked polyubiquitin chains in TRAF6 and links TRAF6 (TNF receptor-associated factor 6) to TAK1 (Transforming growth factor beta-associated kinase 1). TRAF6 ubiquitinates TAK1 on K34 and K158 and this triggers conformational changes in TAK1 that lead to autophosphorylation and activation (Fan et al. 2010, Hamidi et al. 2011).
Landström, M, Barluenga, S, von Bulow, V, Winssinger, N, Hamidi, R, Heldin, CH, Hamidi, A
Xie, M, Fan, Y, Fu, S, Zhang, H, Shi, Y, Mao, R, Ge, N, Sun, W, Schneider, MD, Yang, J, Qin, J, Xu, G, Yu, Y, Chang, A
ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane]
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