Reactome | K63polyUb-TRAF6 ubiquitinates TAK1

K63polyUb-TRAF6 ubiquitinates TAK1

Stable Identifier

R-HSA-5607757

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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TAK1-binding protein 2 (TAB2), or its homologue TAB3, binds preferentially to K63-linked polyubiquitin chains in TRAF6 and links TRAF6 (TNF receptor-associated factor 6) to TAK1 (Transforming growth factor beta-associated kinase 1). TRAF6 ubiquitinates TAK1 on K34 and K158 and this triggers conformational changes in TAK1 that lead to autophosphorylation and activation (Fan et al. 2010, Hamidi et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22069318	Polyubiquitination of transforming growth factor ? (TGF?)-associated kinase 1 mediates nuclear factor-?B activation in response to different inflammatory stimuli Landström, M, Barluenga, S, von Bulow, V, Winssinger, N, Hamidi, R, Heldin, CH, Hamidi, A	J. Biol. Chem.	2012
20038579	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation Xie, M, Fan, Y, Fu, S, Zhang, H, Shi, Y, Mao, R, Ge, N, Sun, W, Schneider, MD, Yang, J, Qin, J, Xu, G, Yu, Y, Chang, A	J. Biol. Chem.	2010