Dectin-1 mediated noncanonical NF-kB signaling

Stable Identifier
Homo sapiens
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In addition to the activation of canonical NF-kB subunits, activation of SYK pathway by Dectin-1 leads to the induction of the non-canonical NF-kB pathway, which mediates the nuclear translocation of RELB-p52 dimers through the successive activation of NF-kB-inducing kinase (NIK) and IkB kinase-alpha (IKKa) (Geijtenbeek & Gringhuis 2009, Gringhuis et al. 2009). Noncanonical activity tends to build more slowly and remain sustained several hours longer than does the activation of canonical NF-kB. The noncanonical NF-kB pathway is characterized by the post-translational processing of NFKB2 (Nuclear factor NF-kappa-B) p100 subunit to the mature p52 subunit. This subsequently leads to nuclear translocation of p52:RELB (Transcription factor RelB) complexes to induce cytokine expression of some genes (C-C motif chemokine 17 (CCL17) and CCL22) and transcriptional repression of others (IL12B) (Gringhuis et al. 2009, Geijtenbeek & Gringhuis 2009, Plato et al. 2013).

Literature References
PubMed ID Title Journal Year
23570314 C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways

Willment, JA, Brown, GD, Plato, A

Int. Rev. Immunol. 2013
19302050 Regulation and function of NF-kappaB transcription factors in the immune system

Karin, M, Vallabhapurapu, S

Annu. Rev. Immunol. 2009
19521399 Signalling through C-type lectin receptors: shaping immune responses

Geijtenbeek, TB, Gringhuis, SI

Nat. Rev. Immunol. 2009
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