Reactome | CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation

Stable Identifier

R-HSA-5607763

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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CLEC7A (Dectin-1) induces NFAT activation

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CLEC7A (Dectin-1) signals through the classic calcineurin/NFAT pathway through Syk activation phospholipase C-gamma 2 (PLCG2) leading to increased soluble IP3 (inositol trisphosphate). IP3 is able to bind endoplasmic Ca2+ channels, resulting in an influx of Ca2+ into the cytoplasm. This increase in calcium concentration induces calcineurin activation and consequently, dephosphorylation of NFAT and its translocation into the nucleus, triggering gene transcription and extracellular release of Interleukin-2 (Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22611159	NFAT control of innate immunity Fric, J, Zelante, T, Wong, AY, Mertes, A, Yu, HB, Ricciardi-Castagnoli, P	Blood	2012
17312158	Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells Goodridge, HS, Simmons, RM, Underhill, DM	J. Immunol.	2007
21728173	CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses Mourão-Sá, D, Robinson, MJ, Zelenay, S, Sancho, D, Chakravarty, P, Larsen, R, Plantinga, M, Van Rooijen, N, Soares, MP, Lambrecht, B, Reis e Sousa, C	Eur. J. Immunol.	2011