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SUFU [ciliary base]
Stable Identifier
R-HSA-5610424
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary base
Synonyms
Suppressor of fused homolog, SUFU_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
pS-GLI1:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
PKA phosphorylates GLI1 (Homo sapiens)
GLI1:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
pS-GLI1:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)
pS-GLI1:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
CK1 phosphorylates p-GLI2 (Homo sapiens)
p4S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p8S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
ub-p11S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
GSK3 phosphorylates p-GLI2 (Homo sapiens)
p11S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p8S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
PKA phosphorylates GLI2 (Homo sapiens)
GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p4S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)
p11S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
ub-p11S-GLI2:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
CK1 phosphorylates p-GLI3 (Homo sapiens)
p10S-GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p6S-GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
4xub-p13S-Gli3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
GSK3 phosphorylates p-GLI3 (Homo sapiens)
p10S-GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p13S-GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
PKA phosphorylates GLI3 (Homo sapiens)
GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p6S-GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)
4xub-p13S-Gli3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
p13S-GLI3:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)
GLI:SUFU [ciliary base] (Homo sapiens)
SUFU [ciliary base] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UMX1 SUFU
Gene Names
SUFU, UNQ650/PRO1280
Chain
chain:1-484
Reference Genes
COSMIC (genes):SUFU SUFU
dbSNP Gene:51684 SUFU
ENSEMBL:ENSG00000107882 SUFU
Participates
as a component of
GLI2:SUFU [ciliary base] (Homo sapiens)
p4S-GLI2:SUFU [ciliary base] (Homo sapiens)
p8S-GLI2:SUFU [ciliary base] (Homo sapiens)
p11S-GLI2:SUFU [ciliary base] (Homo sapiens)
ub-p11S-GLI2:SUFU [ciliary base] (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
pS-GLI1:SUFU [ciliary base] (Homo sapiens)
GLI1:SUFU [ciliary base] (Homo sapiens)
GLI:SUFU [ciliary base] (Homo sapiens)
GLI3:SUFU [ciliary base] (Homo sapiens)
p6S-GLI3:SUFU [ciliary base] (Homo sapiens)
p10S-GLI3:SUFU [ciliary base] (Homo sapiens)
p13S-GLI3:SUFU [ciliary base] (Homo sapiens)
4xub-p13S-Gli3:SUFU [ciliary base] (Homo sapiens)
Other forms of this molecule
SUFU [cytosol]
SUFU [ciliary tip]
Inferred To
Su(fu) [ciliary base]
(Drosophila melanogaster)
Sufu [ciliary base]
(Mus musculus)
Sufu [ciliary base]
(Rattus norvegicus)
SUFU [ciliary base]
(Bos taurus)
SUFU [ciliary base]
(Canis familiaris)
SUFU [ciliary base]
(Gallus gallus)
SUFU [ciliary base]
(Sus scrofa)
sufu [ciliary base]
(Danio rerio)
sufu [ciliary base]
(Xenopus tropicalis)
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08151 GLI1
9
ub-GLI1 [cytosol]
(R-HSA-5635833)
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
GLI1 [cytosol]
(R-HSA-445457)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
GLI1 [ciliary base]
(R-HSA-5610357)
GLI1 [ciliary tip]
(R-HSA-5610360)
0.968
27
UniProt:Q9BV97 ZNF747
1
ZNF747 [nucleoplasm]
(R-HSA-2586596)
0.848
8
UniProt:Q96H86 ZNF764
1
ZNF764 [nucleoplasm]
(R-HSA-3343766)
0.847
9
UniProt:P10071 GLI3
13
GLI3R [nucleoplasm]
(R-HSA-5610371)
GLI3R [cytosol]
(R-HSA-5610369)
ub-p13S-GLI3 [ciliary base]
(R-HSA-5610506)
p13S-GLI3 [ciliary base]
(R-HSA-5610485)
p10S-GLI3 [ciliary base]
(R-HSA-5610454)
p6S-GLI3 [ciliary base]
(R-HSA-5610492)
GLI3 [ciliary base]
(R-HSA-5610365)
GLI3 [ciliary tip]
(R-HSA-5610367)
p-GLI3 [nucleoplasm]
(R-HSA-5635051)
2p-GLI3 [nucleoplasm]
(R-HSA-5635052)
p-GLI3 [ciliary tip]
(R-HSA-5635048)
GLI3 [cytosol]
(R-HSA-206085)
ub-2p-GLI3 [nucleoplasm]
(R-HSA-5635060)
0.773
5
UniProt:Q13515 BFSP2
0.742
6
UniProt:Q96D15 RCN3
0.703
5
UniProt:Q9NWS9-2 ZNF446
0.666
4
UniProt:Q7Z353 HDX
0.666
4
UniProt:Q8TBC5 ZSC18
0.666
4
UniProt:P30307 CDC25C
8
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
CDC25C [cytosol]
(R-HSA-157879)
CDC25C [nucleoplasm]
(R-HSA-69741)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
0.643
3
UniProt:Q86YD7 F90A1
0.643
3
UniProt:O14753 OVOL1
0.641
3
UniProt:P10070 GLI2
11
GLI2 [ciliary tip]
(R-HSA-5610363)
GLI2 [ciliary base]
(R-HSA-5610361)
2p-GLI2 [nucleoplasm]
(R-HSA-5635055)
p-GLI2 [nucleoplasm]
(R-HSA-5635047)
p-GLI2 [ciliary tip]
(R-HSA-5635044)
GLI2 [cytosol]
(R-HSA-445451)
ub-p11S-GLI2 [ciliary base]
(R-HSA-5610501)
p11S-GLI2 [ciliary base]
(R-HSA-5610471)
p8S-GLI2 [ciliary base]
(R-HSA-5610494)
p4S-GLI2 [ciliary base]
(R-HSA-5610487)
ub-2p-GLI2 [nucleoplasm]
(R-HSA-5635059)
0.569
3
UniProt:Q12968 NFATC3
3
p-13S-NFATC3 [cytosol]
(R-HSA-2025920)
p-S265-NFATC3 [cytosol]
(R-HSA-2685614)
p-S265-NFATC3 [nucleoplasm]
(R-HSA-2025988)
0.564
2
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:Q96GZ6 S41A3
0.556
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:O95678 KRT75
1
KRT75 [cytosol]
(R-HSA-6809652)
0.556
3
UniProt:O00746 NME4
1
NME4 [mitochondrial inner membrane]
(R-HSA-60026)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9UJ55 MAGL2
0.556
3
UniProt:Q9P2A4 ABI3
0.556
3
UniProt:Q86VQ0 LCA5
0.556
3
UniProt:Q0D2J5 ZN763
0.556
3
UniProt:Q8N4C7 STX19
0.556
3
UniProt:Q53ET0 CRTC2
1
CRTC2 [nucleoplasm]
(R-HSA-8931951)
0.556
5
UniProt:Q96JM7-2 L3MBTL3
0.556
3
UniProt:O43186 CRX
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q9Y3S2 ZN330
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:Q8NC26 ZNF114
1
ZNF114 [nucleoplasm]
(R-HSA-975026)
0.556
3
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:O14978 ZNF263
1
ZNF263 [nucleoplasm]
(R-HSA-1027393)
0.553
2
UniProt:Q8NEA6 GLIS3
0.553
3
UniProt:Q9NPA3 MID1IP1
1
MID1IP1 [cytosol]
(R-HSA-8867328)
0.547
3
UniProt:Q9NRP7 STK36
0.536
3
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
2
UniProt:P30837 ALDH1B1
1
ALDH1B1 [mitochondrial matrix]
(R-HSA-5696097)
0.527
2
UniProt:O14771 ZNF213
1
ZNF213 [nucleoplasm]
(R-HSA-1027351)
0.527
3
UniProt:Q1X8D7 LRC36
0.527
2
UniProt:O60293 ZC3H1
0.527
3
UniProt:Q16822 PCK2
1
PCK2 [mitochondrial matrix]
(R-HSA-372815)
0.527
3
UniProt:Q9Y466 NR2E1
1
NR2E1 [nucleoplasm]
(R-HSA-376207)
0.527
2
UniProt:O95157 NXPH3
0.527
3
UniProt:Q9Y234 LIPT1
1
LIPT1 [mitochondrial matrix]
(R-HSA-6792623)
0.527
2
UniProt:Q92611 EDEM1
1
EDEM1 [endoplasmic reticulum quality control compartment]
(R-HSA-381083)
0.527
2
UniProt:P12644 BMP4
4
BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956775)
p-BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956944)
BMP4 [extracellular region]
(R-HSA-8858573)
BMP4(20-408) [extracellular region]
(R-HSA-2396280)
0.527
3
UniProt:Q7Z412 PEX26
2
PEX26 [cytosol]
(R-HSA-9603779)
PEX26 [peroxisomal membrane]
(R-HSA-9033092)
0.508
2
UniProt:Q0VGT2 Gli2
13
phospho-Gli2 [nucleoplasm]
(R-MMU-5635059)
ub-p11S-Gli2 [cytosol]
(R-MMU-5610503)
p11S-Gli2 [cytosol]
(R-MMU-5610476)
p8S-Gli2 [cytosol]
(R-MMU-5610496)
p4S-Gli2 [cytosol]
(R-MMU-5610489)
Gli2 [cytosol]
(R-MMU-5610376)
Gli2 [nucleoplasm]
(R-MMU-3900178)
Gli2 [cytosol]
(R-MMU-445451)
phospho-Gli2 [ciliary tip]
(R-MMU-5635044)
phospho-Gli2 [nucleoplasm]
(R-MMU-5635047)
phospho-Gli2 [nucleoplasm]
(R-MMU-5635055)
Gli2 [ciliary base]
(R-MMU-5610361)
Gli2 [ciliary tip]
(R-MMU-5610363)
0.463
3
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