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Organic anion transport
Stable Identifier
R-HSA-561048
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic anion transport (Homo sapiens)
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Organic anion transporters (OATs) mediate the renal absorption and excretion of a broad range of endogenous substrates and anionic drugs such as diuretics and NSAIDs. Five members belong to these polyspecific transporters (OAT1-4 and URAT1) and are predominantly expressed in the kidney (Koepsell H and Endou H, 2004; Rizwan AN and Burckhardt G, 2007; Ahn SY and Bhatnagar V, 2008).
Literature References
PubMed ID
Title
Journal
Year
18695391
Update on the molecular physiology of organic anion transporters
Bhatnagar, V
,
Ahn, SY
Curr Opin Nephrol Hypertens
2008
17245646
Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles
Rizwan, AN
,
Burckhardt, G
Pharm Res
2007
12883891
The SLC22 drug transporter family
Koepsell, H
,
Endou, H
Pflugers Arch
2004
Participants
Events
OAT1-3 transport organic anions with antiport of dicarboxylic acids
(Homo sapiens)
OAT2 and OAT4 mediate transport of sulphate conjugates
(Homo sapiens)
SLC22A12 exchanges extracellular urate for cytosolic LACT
(Homo sapiens)
Participates
as an event of
Organic cation/anion/zwitterion transport (Homo sapiens)
Orthologous Events
Organic anion transport (Bos taurus)
Organic anion transport (Caenorhabditis elegans)
Organic anion transport (Canis familiaris)
Organic anion transport (Danio rerio)
Organic anion transport (Drosophila melanogaster)
Organic anion transport (Gallus gallus)
Organic anion transport (Mus musculus)
Organic anion transport (Rattus norvegicus)
Organic anion transport (Sus scrofa)
Organic anion transport (Xenopus tropicalis)
Authored
Jassal, B (2010-03-25)
Reviewed
He, L (2010-05-10)
Created
Jassal, B (2010-03-25)
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