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NUMB:ITCH [cytosol]
Stable Identifier
R-HSA-5610562
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB binds ITCH (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
NUMB binds ITCH (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH binds GLI1 (Homo sapiens)
GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)
GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
ub-GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
ub-GLI is degraded by the proteasome (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
ub-GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
Participants
components
ITCH [cytosol]
(Homo sapiens)
NUMB [plasma membrane]
(Homo sapiens)
Participates
as an output of
ub-GLI is degraded by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
NUMB binds ITCH (Homo sapiens)
as a component of
ub-GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
as an input of
NUMB:ITCH binds GLI1 (Homo sapiens)
NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)
Inferred To
NUMB:ITCH [cytosol]
(Bos taurus)
NUMB:ITCH [cytosol]
(Canis familiaris)
NUMB:ITCH [cytosol]
(Danio rerio)
NUMB:ITCH [cytosol]
(Drosophila melanogaster)
NUMB:ITCH [cytosol]
(Gallus gallus)
NUMB:ITCH [cytosol]
(Mus musculus)
NUMB:ITCH [cytosol]
(Rattus norvegicus)
NUMB:ITCH [cytosol]
(Sus scrofa)
NUMB:ITCH [cytosol]
(Xenopus tropicalis)
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