Reactome | CK1 phosphorylates p-GLI2

CK1 phosphorylates p-GLI2

Stable Identifier

R-HSA-5610718

Type

Reaction [transition]

Species

Homo sapiens

Compartment

ciliary base

ReviewStatus

5/5

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Phosphorylation by PKA primes GLI2 for subsequent phosphorylation at adjacent CK sites (Pan et al, 2006; Pan and Wang, 2007).

Literature References

PubMed ID	Title	Journal	Year
17283082	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome Pan, Y, Wang, B	J. Biol. Chem.	2007
16611981	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Pan, Y, Bai, CB, Wang, B, Joyner, AL	Mol. Cell. Biol.	2006

Participants

Input

Output

Participates

as an event of

Degradation of GLI2 by the proteasome (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of CSNK1A1 [cytosol]

Physical Entity

CSNK1A1 [cytosol] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Inferred From

CK1 phosphorylates p-Gli2 (Mus musculus)

Authored

Rothfels, K (2014-05-07)

Reviewed

Liu, Y C (2014-08-01)

Created

Rothfels, K (2014-07-23)

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