Phosphorylation of GLI3 by PKA on up to six sites in the C-terminal region primes the protein for subsequent phosphorylation by CK1 and GSK3 and is required for the ubiquitin-mediated processing by the proteasome to yield the truncated repressor form (Tempe et al, 2006; Pan et al, 2006; Pan and Wang, 2007; Wang and Li, 2006). Processing of GLI3 is regulated in part by movement through the primary cilia, and disruption of intraflagellar transport abrogates processing (Wen et al, 2010)
Tempe, D, Concordet, JP, Casas, M, Blanchet-Tournier, MF, Karaz, S
Pan, Y, Wang, B
Scales, SJ, Hongo, JA, Wen, X, Evangelista, M, Lai, CK, de Sauvage, FJ
Pan, Y, Bai, CB, Wang, B, Joyner, AL
Wang, B, Li, Y
cAMP-dependent protein kinase activity of PKA catalytic subunit [ciliary base]
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