Reactome | CK1 phosphorylates p-GLI3

CK1 phosphorylates p-GLI3

Stable Identifier

R-HSA-5610722

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation by PKA primes GLI3 for subsequent phosphorylation by CK1 at four or more sites. These serial phosphorylations are required for the recruitment of beta-TrCP and subsequent ubiquitination and processing of GLI3 (Tempe et al, 2006; Wang and Li, 2006; Wen et al, 2010; Schrader et al, 2011)

Literature References

PubMed ID	Title	Journal	Year
16705181	Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP Tempe, D, Concordet, JP, Casas, M, Blanchet-Tournier, MF, Karaz, S	Mol Cell Biol	2006
20154143	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Scales, SJ, Hongo, JA, Wen, X, Evangelista, M, Lai, CK, de Sauvage, FJ	Mol. Cell. Biol.	2010
21921029	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome Matouschek, A, Holmgren, RA, Schrader, EK, Harstad, KG	J. Biol. Chem.	2011
16371461	Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing Wang, B, Li, Y	Proc. Natl. Acad. Sci. U.S.A.	2006