SCF(beta-TrCP) ubiquitinates p-GLI2

Stable Identifier
R-HSA-5610745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ciliary base
ReviewStatus
5/5
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SCF(beta-TrCP) ubiquitinates p-GLI2
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GLI2 interacts directly with beta-TrCP and is polyubiquitinated in a phosphorylation-dependent manner. Binding and ubiquitination by beta-TrCP depends on 2 motifs located in the region of GLI2 phosphorylated by PKA, CK1 and GSK3 (Pan et al, 2006).

Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Wang, B, Joyner, AL

Mol. Cell. Biol. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]

Physical Entity
BTRC:CUL1:RBX1:SKP1 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Inferred From
SCF(beta-TrCP) ubiquitinates p-Gli2 (Homo sapiens)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
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