Reactome | FHL2 [nucleoplasm]

FHL2 [nucleoplasm]

Stable Identifier

R-HSA-561161

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Four and a half LIM domains protein 2, FHL2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NTW7 ZF64B

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External Reference Information

External Reference

UniProt:Q14192 FHL2

Gene Names

FHL2, DRAL, SLIM3

Chain

chain:1-279

Reference Genes

BioGPS Gene:2274 FHL2

COSMIC (genes):FHL2 FHL2

CTD Gene:2274 FHL2

dbSNP Gene:2274 FHL2

ENSEMBL:ENSG00000115641 FHL2

HGNC:3703 FHL2

KEGG:hsa:2274 FHL2

Monarch:2274 FHL2

NCBI Gene:2274 FHL2

OMIM:602633 FHL2

UCSC:Q14192 FHL2

Reference Transcript

Other Identifiers

11741105_a_at

11741106_x_at

11756134_a_at

16901393

202949_PM_s_at

202949_s_at

2274

2568688

2568689

2568690

2568691

2568692

2568693

2568694

2568695

2568696

2568697

2568698

2568700

2568703

2568704

2568709

2568715

2568716

2568717

2568718

2568721

2568725

2568726

2568727

2568728

2568729

2568730

2568731

2568737

2568739

2568741

2568742

2568745

2568746

2568774

38422_s_at

8054377

A_23_P108751

A_33_P3362321

A_33_P3362326

GE473731

GE61139

GO:0000122

GO:0001649

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005925

GO:0006355

GO:0006357

GO:0008134

GO:0008270

GO:0009725

GO:0030018

GO:0030154

GO:0042802

GO:0043066

GO:0043425

GO:0046872

GO:0048856

GO:0055014

GO:0055015

GO:0060347

GO:0070885

HMNXSV003012326

HMNXSV003015983

ILMN_1668411

ILMN_1678643

ILMN_2265783

ILMN_2355831

L42176_at

PH_hs_0000884

g4503722_3p_a_at

Participates

as an output of

Expression of FHL2 (Homo sapiens)

Cross References

RefSeq

XP_011509100.1, NP_963851.2, NP_001305825.1, NP_001361328.1, NP_001305823.1, NP_001305826.1, NP_001305824.1, NP_001034581.1, NP_001441.4, NP_963849.1

OpenTargets

ENSG00000115641

ENSEMBL

ENSP00000386633, ENST00000530340, ENST00000409807, ENSP00000377020, ENSP00000386665, ENSP00000377021, ENST00000393352, ENSP00000350846, ENSP00000344266, ENST00000393353, ENSP00000433567, ENST00000322142, ENSG00000115641, ENSP00000322909, ENST00000409177, ENST00000344213, ENSP00000386892, ENST00000358129, ENST00000408995

GeneCards

FHL2

HPA

ENSG00000115641-FHL2

PRO

Q14192

Pharos - Targets

Q14192

GlyGen

Q14192

Orphanet

FHL2

PDB

2MIU, 2D8Z, 1X4K, 1X4L

Interactors (155)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48380 RFX3			0.904	12
UniProt:Q9UBI6 GNG12	1	GNG12 [plasma membrane] (R-HSA-164367)	0.83	11
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.781	10
UniProt:P14923 JUP	7	JUP [plasma membrane] (R-HSA-437260) JUP [cytosol] (R-HSA-201598) p-Y-JUP [cytosol] (R-HSA-9934829) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739)	0.781	7
UniProt:Q9Y5P3 RAI2			0.781	7
UniProt:Q53HC0 CCD92			0.781	10
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.743	7
UniProt:Q9NTW7 ZF64B			0.742	8
UniProt:Q9NYN1 RASLC			0.742	6
UniProt:Q8N9N5-2 BANP			0.718	6
UniProt:Q63ZY3 KANK2			0.718	6
UniProt:Q9BZQ8 NIBA1			0.718	6
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.718	10
UniProt:P52739-2 ZNF131			0.718	6
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.715	6
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.683	4
UniProt:O75398 DEAF1			0.675	4
UniProt:P05814 CSN2	2	CSN2 [secretory granule lumen] (R-HSA-9962439) CSN2 [extracellular region] (R-HSA-1254293)	0.666	4
UniProt:Q9Y4X4 KLF12			0.666	5
UniProt:Q0VD86 INCA1			0.666	5
UniProt:P55347 PKNOX1	1	PKNOX1 [nucleoplasm] (R-HSA-5617496)	0.666	5
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733)	0.666	5
UniProt:P36508 ZNF76			0.666	4
UniProt:Q96BD5 PHF21A	1	PHF21A [nucleoplasm] (R-HSA-996754)	0.666	5
UniProt:Q49A26 GLYR1			0.666	4
UniProt:Q02086 SP2			0.666	4
UniProt:Q2TAL8 QRIC1			0.666	5
UniProt:Q8IYX7 SAXO1			0.666	4
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.666	5
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.666	4
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.666	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.659	10
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.645	8
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.639	8
UniProt:Q9C0C2 TNKS1BP1	1	TNKS1BP1 [cytosol] (R-HSA-430011)	0.623	8
UniProt:B4DE54 B4DE54			0.601	4
UniProt:P51610-1 HCFC1			0.593	5
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.593	3
UniProt:Q06546 GABPA	1	GABPA [nucleoplasm] (R-HSA-1592206)	0.59	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.59	3
UniProt:A1E959 ODAM	1	ODAM [extracellular region] (R-HSA-977149)	0.564	2
UniProt:P98182 ZNF200	1	ZNF200 [nucleoplasm] (R-HSA-974991)	0.556	3
UniProt:Q96JP2 MY15B			0.556	5
UniProt:O43699 SIGLEC6	1	SIGLEC6 [plasma membrane] (R-HSA-197708)	0.556	3
UniProt:Q8IVT2 MISP			0.556	3
UniProt:P50150 GNG4	1	GNG4 [plasma membrane] (R-HSA-164350)	0.556	3
UniProt:O14639-4 ABLIM1			0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q3KP44 ANR55			0.556	3
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097) LDLRAP1 [plasma membrane] (R-HSA-171143)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:E9PSE9 E9PSE9			0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q8IZP0-5 ABI1			0.556	3
UniProt:Q49A26-4 GLYR1			0.556	3
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:O75155 CAND2			0.556	3
UniProt:O75031 HSF2B			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q49A12 Q49A12			0.556	3
UniProt:Q8TAG6 VEXIN			0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
UniProt:O94993 SOX30			0.556	3
UniProt:Q9H1P6 CMIP1			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q9BRR9 ARHGAP9	3	ARHGAP9 [secretory granule lumen] (R-HSA-6804973) ARHGAP9 [extracellular region] (R-HSA-6806529) ARHGAP9 [cytosol] (R-HSA-2976572)	0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q9UKD1 GMEB2			0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
IntAct:EBI-22381398 CCSB ORF ID			0.556	3
UniProt:Q6MZQ0 PRR5L			0.556	3
UniProt:Q9H8W3 F204A			0.556	3
UniProt:Q86UV6-2 TRIM74			0.556	3
UniProt:Q5T3J3 LRIF1			0.556	3
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:Q658L1 SAXO2			0.556	3
UniProt:Q9NQV5 PRD11			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q9UMQ3 BARX2			0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:W5RWE1 W5RWE1			0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
IntAct:EBI-22343137 CCSB ORF ID			0.556	3
UniProt:Q5VZL5 ZMYM4			0.556	3
UniProt:Q6IS01 Q6IS01			0.556	3
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q9NQ31 AKIP1			0.556	3
UniProt:Q16656-4 NRF1			0.556	3
UniProt:A0PJW8 DAPL1			0.556	3
UniProt:Q02086-2 SP2			0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:P80217-2 IFI35			0.556	5
UniProt:Q86VQ6 TRXR3			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	6
UniProt:Q9UJ55 MAGL2			0.556	3
UniProt:Q14005-2 IL16			0.556	3
UniProt:A0A0S2Z5G4 A0A0S2Z5G4			0.556	3
UniProt:P33176 KIF5B	3	KIF5B [cytosol] (R-HSA-265181) KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] (R-HSA-9711937) KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] (R-HSA-9711964)	0.556	3
UniProt:P13984 GTF2F2	1	GTF2F2 [nucleoplasm] (R-HSA-65567)	0.556	3
UniProt:P17027 ZNF23	1	ZNF23 [nucleoplasm] (R-HSA-1027395)	0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:Q7Z3K3 POGZ			0.556	3
UniProt:Q0D2K3 RIPP1			0.556	3
UniProt:Q8N9N5-7 BANP			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q7L5A3 ATOSB			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:Q9NQ94 A1CF	1	A1CF [nucleoplasm] (R-HSA-3211440)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	5
UniProt:P52739 ZNF131	2	ZNF131 [nucleoplasm] (R-HSA-3296168) monoSUMO1-K601-ZNF131 [nucleoplasm] (R-HSA-3296152)	0.547	3
UniProt:Q9NYA1 SPHK1	4	p-S225-SPHK1 [cytosol] (R-HSA-5218716) p-S225-SPHK1 [nucleoplasm] (R-HSA-9836613) SPHK1 [nucleoplasm] (R-HSA-9836616) SPHK1 [cytosol] (R-HSA-391267)	0.543	7
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.527	2
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.527	3
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.527	3
UniProt:Q8WVH0 CPLX3			0.527	2
UniProt:A2VCK2 DCD2B			0.527	2
UniProt:Q7Z6M3 MILR1			0.527	2
UniProt:Q96FX7 TRMT61A	1	TRMT61A [nucleoplasm] (R-HSA-6783477)	0.527	2
UniProt:Q9BRK5 CAB45			0.527	2
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.527	3
UniProt:P60321 NANO2			0.527	2
UniProt:A5YKK6 CNOT1	1	CNOT1 [cytosol] (R-HSA-429892)	0.527	3
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.527	3
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.527	2
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.527	2
UniProt:Q9H410 DSN1	3	DSN1 [cytosol] (R-HSA-375308) DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228)	0.527	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [platelet alpha granule lumen] (R-HSA-8862964) VTI1B [extracellular region] (R-HSA-8862983)	0.527	2
UniProt:P50616 TOB1			0.527	2
UniProt:Q9H3Q1 CDC42EP4	1	CDC42EP4 [cytosol] (R-HSA-9691381)	0.527	2
UniProt:Q9UKZ1 CNOT11	1	CNOT11 [cytosol] (R-HSA-429981)	0.527	3
UniProt:Q8N443 RIBC1			0.527	2
UniProt:Q6NZI2 CAVIN1	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.508	3
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.508	2
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.508	2
UniProt:Q9ERP3 TRI54			0.508	2
UniProt:Q9UBZ9 REV1	1	REV1 [nucleoplasm] (R-HSA-3006726)	0.508	2
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.508	2
UniProt:P26006-1 ITGA3			0.508	2
UniProt:Q9H9D4 ZN408			0.508	3
UniProt:Q13683 ITGA7	1	ITGA7(34-1181) [plasma membrane] (R-HSA-215940)	0.508	2
UniProt:Q13643 FHL3			0.454	2

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