Reactome | GlcNAc,1,2-Man-DAG1 [Golgi lumen]

GlcNAc,1,2-Man-DAG1 [Golgi lumen]

Stable Identifier

R-HSA-5617087

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

Alpha-dystroglycan, Dystroglycan alpha, DAG1_HUMAN, DAG1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14118 DAG1

Gene Names

DAG1

Chain

signal peptide:1-29, chain:30-653, chain:654-895

Reference Genes

BioGPS Gene:1605 DAG1

COSMIC (genes):DAG1 DAG1

CTD Gene:1605 DAG1

dbSNP Gene:1605 DAG1

ENSEMBL:ENSG00000173402 DAG1

HGNC:2666 DAG1

KEGG:hsa:1605 DAG1

Monarch:1605 DAG1

NCBI Gene:1605 DAG1

OMIM:128239 DAG1

UCSC:Q14118 DAG1

Reference Transcript

Participates

as an output of

POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)

Other forms of this molecule

DAG1(654-895) [plasma membrane]

DAG1(30-653) [extracellular region]

DAG1(30-653) [cytosol]

DAG1(30-653) [endoplasmic reticulum lumen]

Man-DAG1 [endoplasmic reticulum lumen]

GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]

Man-DAG1 [Golgi lumen]

GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region]

GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen]

DAG1(654-895) [Golgi membrane]

DAG1(654-895) [endoplasmic reticulum membrane]

DAG1 [endoplasmic reticulum membrane]

Inferred To

Dag1 [Golgi lumen] (Mus musculus)

Dag1 [Golgi lumen] (Rattus norvegicus)

GlcNAc,1,2-Man-DAG1 [Golgi lumen] (Gallus gallus)

dag1 [Golgi lumen] (Danio rerio)

dag1 [Golgi lumen] (Xenopus tropicalis)

dgn-1 [Golgi lumen] (Caenorhabditis elegans)

DAG1 [Golgi lumen] (Bos taurus)

DAG1 [Golgi lumen] (Canis familiaris)

DAG1 [Golgi lumen] (Sus scrofa)

Dg [Golgi lumen] (Drosophila melanogaster)

Modified Residues

Name

O-mannosyl-L-serine (N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl group) at unknown position

Modification

N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl group

PsiMod Name

O-mannosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-mannosylserine.

Cross References

OpenTargets

ENSG00000173402

ENSEMBL

ENST00000452060, ENST00000466701, ENSP00000401382, ENST00000418588, ENSP00000513216, ENST00000430636, ENST00000431960, ENST00000435508, ENSP00000513217, ENST00000496474, ENSP00000501140, ENST00000697271, ENST00000469139, ENSP00000415321, ENSP00000387859, ENSP00000501165, ENSP00000513218, ENSP00000401805, ENSP00000312435, ENSG00000173402, ENSP00000405859, ENST00000421560, ENSP00000388833, ENST00000452317, ENST00000428779, ENST00000308775, ENST00000673708, ENSP00000412067, ENSP00000410145

GeneCards

DAG1

HPA

ENSG00000173402-DAG1

PRO

Q14118

Pharos - Targets

Q14118

GlyGen

Q14118

Orphanet

DAG1

PDB

2MK7, 5GGP, 6JJY, 7E9L, 7E9K, 5LLK, 1EG4

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14118 DAG1	15	DAG1(654-895) [plasma membrane] (R-HSA-2328154) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region] (R-HSA-9913190) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen] (R-HSA-8932424) DAG1(654-895) [Golgi membrane] (R-HSA-9913184) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254)	0.558	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667)	0.527	2
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.527	2
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:Q9Y5F2 PCDBB			0.527	2
UniProt:O95302 FKBP9	1	FKBP9 [cytosol] (R-HSA-391306)	0.527	2
UniProt:Q8WXA8 HTR3C	1	HTR3C [plasma membrane] (R-HSA-975312)	0.527	2
UniProt:Q9NU53 GINM1			0.527	2
UniProt:O00214 LEG8			0.527	2
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	3
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.527	2
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2