HOXB1 gene is transcribed

Stable Identifier
R-HSA-5617454
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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HOXB1 gene is transcribed
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In mouse embryos (PIASxbeta) PIAS2 activates expression of Hoxb1 (Garcia-Dominguez et al. 2006). After activation by retinoic acid, the HOXB1 gene is transcribed to yield mRNA (in embryos in Giampaolo et al. 1989, in human embryonal carcinoma cells in Simeone et al. 1990, Ogura and Evans 1995).
In mouse embryos, Hoxb1 is expressed in mesoderm and neurectoderm of primitive streak stage embryos and then becomes restricted to rhombomeres of the hindbrain. Before rhombomere formation Hoxb1 is initially expressed in the region that becomes r3-7. After rhombomere formation Hoxb1 becomes restricted to r4 and is also observed in caudal mesoderm. In mouse embryos PIASxbeta (PIAS2) activates Hoxb1 expression and Egr2 (Krox20) interferes with this activation (Garcia-Dominguez et al. 2006). In mouse embryonal carcinoma cells and embryos Hoxb3 binds the Hoxb1 gene and negatively regulates transcription (Wong et al. 2011).
Literature References
PubMed ID Title Journal Year
2570724 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system

Giampaolo, A, Acampora, D, Zappavigna, V, Pannese, M, D'Esposito, M, Carè, A, Faiella, A, Stornaiuolo, A, Russo, G, Simeone, A

Differentiation 1989
7831296 A retinoic acid-triggered cascade of HOXB1 gene activation

Ogura, T, Evans, RM

Proc. Natl. Acad. Sci. U.S.A. 1995
1975088 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Simeone, A, Acampora, D, Arcioni, L, Andrews, PW, Boncinelli, E, Mavilio, F

Nature 1990
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HOXB3 [nucleoplasm] (Homo sapiens)
Regulator
EGR2 [nucleoplasm] (Homo sapiens)
Positively by
Regulator
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
RXRA:RARA,G:atRA [nucleoplasm]
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
EP300 [nucleoplasm]
NCOA3 [nucleoplasm]
Regulator
HOXB1:PBX1:PKNOX1 and MEIS1 at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
HOXB1:PBX1:PKNOX1 [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
MEIS1 [nucleoplasm]
Regulator
PIAS2 [nucleoplasm] (Homo sapiens)
Inferred From
Hoxb1 gene is transcribed (Mus musculus)
Authored
May, B  (2014-08-08)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-09)
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