Reactome | HOXA1 mRNA is translated

HOXA1 mRNA is translated

Stable Identifier

R-HSA-5617458

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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The HOXA1 mRNA is translated to yield HOXA1 protein (Chen et al. 2013, Chen et al. 2014). MicroRNAs miR-10a (Garzon et al. 2006), let-7c (Zhan et al. 2013), miR-99 (Chen et al. 2013) and miR-100 (Chen et al. 2014) negatively regulate translation in adult cells, however their roles in embryonic cells are unknown.

Literature References

PubMed ID	Title	Journal	Year
23534758	Let-7c inhibits NSCLC cell proliferation by targeting HOXA1 Yu, J, Qu, Q, Wang, G, Tan, SL, Lou, XY, Liu, YZ, Zhou, HH, Zhan, M	Asian Pac. J. Cancer Prev.	2013
24312487	MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells Adjei, BS, Zhang, L, Wang, A, Jin, Y, Chen, Z, Chen, D, Dragas, D, Zhou, X, Dai, Y	PLoS ONE	2013
16549775	MicroRNA fingerprints during human megakaryocytopoiesis Iuliano, R, Aqeilan, RI, Croce, CM, Cimmino, A, Garzon, R, Calin, GA, Andreeff, M, Liu, CG, Palumbo, T, Marcucci, G, Bhatt, D, Alder, H, Volinia, S, Pichiorri, F, Bloomfield, CD	Proc. Natl. Acad. Sci. U.S.A.	2006
24586203	miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion Yuan, Y, Liang, H, Gupta, S, Sun, Y, Wang, M, Zhang, P, Teruya-Feldstein, J, Zhang, J, Ma, L, Han, Z, Chen, D, You, MJ, Hung, MC	PLoS Genet.	2014