HOXA2 gene is transcribed

Stable Identifier
R-HSA-5617483
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HOXA2 gene is transcribed
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The HOXA2 is transcribed to yield mRNA (in carcinoma cells, Yates et al. 2010). In mouse embryos Hoxa2 mRNA is observed in rhombomere 2 and caudally through posterior hindbrain, spinal cord, larynx, lungs, vertebrae, sternum, and intestine. Hoxa2 mRNA is a target of microRNA miR-3960 in differentiating mouse osteoblasts.
Literature References
PubMed ID Title Journal Year
20085832 Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8

Thompson, BA, Yates, JA, Bochar, DA, Menon, T

FEBS Lett. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
HOXB1:PBX1:PKNOX1 [nucleoplasm]
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Regulator
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Inferred From
Hoxa2 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-12)
Cite Us!