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Go!
BBS1 [cytosol]
Stable Identifier
R-HSA-5617640
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
GO Cellular Component
ciliary basal body
(0036064)
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [ciliary membrane] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
LZTFL1 oligomer:BBSome [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
BBSome binds RAB3IP (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
RAB3IP:BBSome [ciliary basal body] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
Formation of the BBSome (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
LZTFL1 oligomer:BBSome [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
BBS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NFJ9 BBS1
Gene Names
BBS1, BBS2L2
Chain
initiator methionine:, chain:2-593
Reference Genes
BioGPS Gene:582 BBS1
COSMIC (genes):BBS1 BBS1
CTD Gene:582 BBS1
dbSNP Gene:582 BBS1
ENSEMBL:ENSG00000174483 BBS1
HGNC:966 BBS1
Monarch:582 BBS1
NCBI Gene:582 BBS1
OMIM:209901 BBS1
UCSC:Q8NFJ9 BBS1
Reference Transcript
RefSeq:NM_024649.4 BBS1
Other Identifiers
11719453_a_at
11719454_a_at
11719455_x_at
11749359_a_at
11760788_a_at
11760789_x_at
11761558_at
11762231_x_at
16727462
218471_PM_s_at
218471_s_at
222643_PM_s_at
222643_s_at
3336278
3336279
3336280
3336281
3336282
3336283
3336284
3336285
3336286
3336287
3336288
3336289
3336290
3336291
3336292
3336293
3336294
3336295
3336296
3336297
3336298
3336299
3336300
3336301
3336302
3336303
3336304
3336306
3336307
3336308
3336309
3336310
3336311
3336316
3336317
3336318
3336319
53099_at
582
65526_at
7941639
A_14_P132172
A_23_P150267
A_24_P184305
A_33_P3316480
GE691756
GE88619
GO:0000226
GO:0001764
GO:0001895
GO:0005102
GO:0005113
GO:0005119
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0005930
GO:0006629
GO:0007010
GO:0007601
GO:0007608
GO:0008104
GO:0008594
GO:0009566
GO:0015031
GO:0016192
GO:0016358
GO:0021591
GO:0021756
GO:0021766
GO:0021987
GO:0022414
GO:0030030
GO:0030154
GO:0030534
GO:0031514
GO:0034451
GO:0034464
GO:0034976
GO:0042048
GO:0042445
GO:0043001
GO:0043226
GO:0044255
GO:0044782
GO:0045444
GO:0045494
GO:0048854
GO:0048856
GO:0048870
GO:0050877
GO:0051216
GO:0051219
GO:0060041
GO:0060170
GO:0060271
GO:0060296
GO:0061351
GO:0061512
GO:0061629
GO:0072659
GO:1905515
HMNXSV003027322
HMNXSV003049281
Hs.54890.0.A1_3p_a_at
Hs.54890.0.A1_3p_x_at
ILMN_1800590
PH_hs_0031688
TC11003432.hg
g13375892_3p_a_at
Participates
as an input of
Formation of the BBSome (Homo sapiens)
as a component of
BBSome [cytosol] (Homo sapiens)
Inferred To
Bbs1 [cytosol]
(Mus musculus)
Bbs1 [cytosol]
(Rattus norvegicus)
BBS1 [cytosol]
(Bos taurus)
BBS1 [cytosol]
(Canis familiaris)
BBS1 [cytosol]
(Drosophila melanogaster)
BBS1 [cytosol]
(Sus scrofa)
Ghost homologue of BBS1 [cytosol]
(Gallus gallus)
bbs1 [cytosol]
(Danio rerio)
bbs1 [cytosol]
(Xenopus tropicalis)
bbs-1 [cytosol]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000393994
,
ENST00000318312
,
ENSP00000377563
,
ENSP00000317469
OpenTargets
ENSG00000174483
HPA
ENSG00000174483-BBS1
PRO
Q8NFJ9
Pharos - Targets
Q8NFJ9
Orphanet
BBS1
PDB
6XT9
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q3SYG4 BBS9
1
BBS9 [cytosol]
(R-HSA-5617630)
0.93
15
UniProt:Q96RK4 BBS4
1
BBS4 [cytosol]
(R-HSA-5617635)
0.893
11
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.883
11
UniProt:Q8N3I7 BBS5
1
BBS5 [cytosol]
(R-HSA-5617633)
0.865
11
UniProt:Q9BXC9 BBS2
1
BBS2 [cytosol]
(R-HSA-5617637)
0.846
10
UniProt:Q8TAM2 TTC8
1
TTC8 [cytosol]
(R-HSA-5617600)
0.823
7
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.666
4
UniProt:Q9H0F7 ARL6
2
ARL6 [cilium]
(R-HSA-5617766)
ARL6 [plasma membrane]
(R-HSA-5624078)
0.649
4
UniProt:Q9H0F7-1 ARL6
0.618
3
UniProt:Q15154 PCM1
1
PCM1 [cytosol]
(R-HSA-380308)
0.573
2
UniProt:Q15051 IQCB1
1
IQCB1 [cytosol]
(R-HSA-5626648)
0.571
4
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:P05062 ALDOB
3
ALDOB A174D [cytosol]
(R-HSA-5656456)
ALDOB A149P [cytosol]
(R-HSA-5656457)
ALDOB [cytosol]
(R-HSA-70339)
0.543
4
UniProt:P61006 RAB8A
6
RAB8A [Golgi membrane]
(R-HSA-2562535)
RAB8A [cytosol]
(R-HSA-5623399)
GGC-RAB8A [cytosol]
(R-HSA-8874063)
GGC-RAB8A [trans-Golgi network membrane]
(R-HSA-8876082)
RAB8A [recycling endosome membrane]
(R-HSA-8854145)
GGC-RAB8A [cytoplasmic vesicle membrane]
(R-HSA-1445093)
0.508
2
UniProt:Q9NQ48 LZTFL1
1
LZTFL1 [cytosol]
(R-HSA-5617789)
0.508
3
UniProt:Q6PI48 DARS2
1
DARS2 [mitochondrial matrix]
(R-HSA-379679)
0.508
2
UniProt:Q9BV68 RNF126
1
RNF126 [cytosol]
(R-HSA-8851642)
0.508
2
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.508
3
UniProt:P48356-1 Lepr
2
p-Y985,Y1077,Y1138-Lepr [plasma membrane]
(R-MMU-2586509)
Lepr (long isoform) [plasma membrane]
(R-MMU-2586522)
0.463
3
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