Reactome | BBSome binds RAB3IP

BBSome binds RAB3IP

Stable Identifier

R-HSA-5617815

Type

Reaction [binding]

Species

Homo sapiens

Compartment

ciliary basal body

ReviewStatus

5/5

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The BBS1 component of the BBSome complex binds RAB3IP, a GEF for the small GTPase RAB8A. RAB3IP is required for RAB8A to localize to the cilium, and depletion of RAB3IP compromises cilia formation (Nachury et al, 2007; Loktev et al, 2008). GTP-bound RAB8A may promote ciliogenesis by promoting the traffic of post-Golgi vesicles to the base of the cilium (Nachury et al, 2007; reviewed in Zerial and McBride, 2001; Ishikawa et al, 2011; Hsiao et al, 2012; Sung and Leroux, 2013).

Literature References

PubMed ID	Title	Journal	Year
21427764	Ciliogenesis: building the cell's antenna Ishikawa, H, Marshall, WF	Nat. Rev. Mol. Cell Biol.	2011
23351793	Trafficking in and to the primary cilium Hsiao, YC, Tuz, K, Ferland, RJ	Cilia	2012
24296415	The roles of evolutionarily conserved functional modules in cilia-related trafficking Sung, CH, Leroux, MR	Nat. Cell Biol.	2013
11252952	Rab proteins as membrane organizers Zerial, M, McBride, H	Nat. Rev. Mol. Cell Biol.	2001
17574030	A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis Westlake, CJ, Loktev, AV, Zhang, Q, Sheffield, VC, Scheller, RH, Slusarski, DC, Nachury, MV, Jackson, PK, Peränen, J, Bazan, JF, Merdes, A	Cell	2007
19081074	A BBSome subunit links ciliogenesis, microtubule stability, and acetylation Scheetz, TE, Searby, CC, Loktev, AV, Zhang, Q, Sheffield, VC, Nachury, MV, Slusarski, DC, Jackson, PK, Beck, JS, Bazan, JF	Dev. Cell	2008