Reactome | FKBP5 [cytosol]

FKBP5 [cytosol]

Stable Identifier

R-HSA-5618096

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FKBP51, 51 kDa FK506-binding protein, AIG6, 54 kDa progesterone receptor-associated immunophilin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13451 FKBP5

Gene Names

FKBP5, AIG6, FKBP51

Chain

chain:1-457

Reference Genes

BioGPS Gene:2289 FKBP5

COSMIC (genes):FKBP5 FKBP5

CTD Gene:2289 FKBP5

dbSNP Gene:2289 FKBP5

ENSEMBL:ENSG00000096060 FKBP5

ENSEMBL_homo_sapiens_GENE:ENSG00000096060.15 FKBP5

HGNC:3721 FKBP5

KEGG Gene (Homo sapiens):2289 FKBP5

Monarch:2289 FKBP5

NCBI Gene:2289 FKBP5

OMIM:602623 FKBP5

UCSC:Q13451 FKBP5

Reference Transcript

Other Identifiers

11739084_at

11739565_a_at

11739566_a_at

11739567_s_at

11743917_a_at

11746275_a_at

204560_PM_at

204560_at

224840_PM_at

224840_at

224856_PM_at

224856_at

2289

2951572

2951573

2951574

2951575

2951576

2951577

2951578

2951579

2951580

2951581

2951582

2951583

2951587

2951589

2951590

2951593

2951595

2951596

2951601

2951603

2951630

2951635

2951640

2951654

2951656

2951657

34721_at

46271_at

8125919

A_21_P0000010

A_23_P111206

A_24_P38081

GE543138

GE562546

GO:0003755

GO:0003824

GO:0005515

GO:0005528

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006457

GO:0009617

GO:0016020

GO:0016853

GO:0031072

GO:0043226

GO:0061077

GO:0070062

GO:0140096

HMNXSV003020481

HMNXSV003042476

Hs.7557.1.A1_3p_at

Hs.7557.1.A2_3p_at

ILMN_1778444

PH_hs_0000782

TC06004150.hg

U42031_at

g4758383_3p_at

Participates

as an input of

FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)

as a component of

as an output of

Other forms of this molecule

FKBP5 [nucleoplasm]

Inferred To

Fkbp59 [cytosol] (Drosophila melanogaster)

FKBP5 [cytosol] (Bos taurus)

FKBP5 [cytosol] (Sus scrofa)

Fkbp5 [cytosol] (Mus musculus)

Fkbp5 [cytosol] (Rattus norvegicus)

Ghost homologue of FKBP5 [cytosol] (Caenorhabditis elegans)

Ghost homologue of FKBP5 [cytosol] (Danio rerio)

Ghost homologue of FKBP5 [cytosol] (Dictyostelium discoideum)

Ghost homologue of FKBP5 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of FKBP5 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of FKBP5 [cytosol] (Xenopus tropicalis)

FKBP35 [cytosol] (Plasmodium falciparum)

FKBP51 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_004108.1, NP_001139248.1, NP_001139247.1, NP_001139249.1

ZINC - World Drugs

FKBP5_HUMAN

Guide to Pharmacology - Targets

3175

OpenTargets

ENSG00000096060

ZINC - FDA approved

FKBP5_HUMAN

ZINC - Substances

FKBP5_HUMAN

ZINC target

Q13451

PRO

Q13451

PDB

3O5L, 4JFI, 4DRI, 8CHN, 4JFJ, 4R0X, 3O5K, 8PC2, 3O5M, 7B9Z, 4DRK, 7B9Y, 3O5I, 7APW, 4DRH, 8FFW, 3O5J, 5OMP, 4TW7, 6TX7, 6TX5, 8PJA, 4JFM, 7ETV, 6TX6, 7A6X, 4TX0, 8BA6, 4JFL, 4DRN, 4DRM, 7ETU, 6SAF, 5OBK, 7ETT, 5NJX, 5BXJ, 4JFK, 8CCD, 4W9Q, 8CCC, 8CCB, 4W9P, 7AOU, 4W9O, 7AWF, 8BAJ, 6TX9, 4DRP, 6TX8, 4DRQ, 4TW6, 8CCA, 1KT0, 3O5F, 3O5Q, 8CCH, 8CHR, 8PJ8, 7APS, 5DIV, 3O5R, 7AOT, 7APT, 4DRO, 3O5G, 3O5D, 8CCG, 7L7I, 3O5O, 8CCF, 8CHQ, 6TXX, 8CHP, 7APQ, 5DIU, 7AWX, 3O5P, 7BA0, 7A6W, 7R0L, 3O5E, 5DIT, 6TX4, 8CCE

IntEnz

5.2.1.8

GeneCards

Q13451

HPA

ENSG00000096060-FKBP5

Ensembl

ENSP00000349811, ENST00000539068, ENSP00000441205, ENST00000357266, ENSP00000444810, ENST00000542713, ENST00000536438, ENSP00000442340, ENSG00000096060

Pharos - Targets

Q13451

ZINC - Predictions - Purchasable

FKBP5_HUMAN

HMDB Protein

HMDBP10673

Interactors (75)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.899	10
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.899	10
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.887	17
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.8	9
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.784	6
UniProt:P00540 MOS			0.744	5
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830)	0.725	5
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.698	8
UniProt:Q9BTE3-2 MCMBP			0.675	4
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.669	7
UniProt:Q96Q40 CDK15			0.669	5
UniProt:P49761 CLK3			0.643	4
UniProt:Q9BXA6 TSSK6			0.643	4
UniProt:Q96QS6 PSKH2			0.643	4
UniProt:Q9BTE3 MCMBP			0.643	5
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.643	4
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.643	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.643	4
UniProt:Q9HBY8 SGK2	1	SGK2 [cytosol] (R-HSA-2682364)	0.643	3
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.643	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.643	4
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.643	4
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.643	3
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.643	3
UniProt:Q00532 CDKL1			0.643	4
UniProt:Q9UQ88 CDK11A	1	CDK11A [cytosol] (R-HSA-380457)	0.643	4
UniProt:Q6PHR2 ULK3	1	ULK3 [ciliary tip] (R-HSA-5635039)	0.623	3
UniProt:Q9UPZ9 CILK1			0.623	3
UniProt:O15197 EPHB6	6	EPHB6 (?-?) [plasma membrane] (R-HSA-3928399) EPHB6 (?-1021) [cytosol] (R-HSA-3928398) EPHB6 (?-1021) [plasma membrane] (R-HSA-3928469) EPHB6 (32-?) [extracellular region] (R-HSA-3928437) EPHB6 [plasma membrane] (R-HSA-2682336) p-Y645,Y651-EPHB6 [plasma membrane] (R-HSA-3928334)	0.569	3
UniProt:P11216 PYGB	4	PXLP-PYGB [extracellular region] (R-HSA-6801536) PXLP-PYGB [azurophil granule lumen] (R-HSA-6799164) PXLP-p-S15-PYGB [cytosol] (R-HSA-71868) PXLP-PYGB [cytosol] (R-HSA-71862)	0.564	2
UniProt:O00141 SGK1	4	SGK1 [cytosol] (R-HSA-2682356) p-S422-SGK1 [cytosol] (R-HSA-6795313) p-T256,S422-SGK1 [cytosol] (R-HSA-6795449) p-T256,S422-SGK1 [nucleoplasm] (R-HSA-9612512)	0.564	2
UniProt:Q70CQ1 USP49	1	USP49 [nucleoplasm] (R-HSA-5696973)	0.564	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.564	2
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.564	2
ChEBI:47785 AMP-PNP			0.544	2
ChEBI:16761 ADP			0.544	2
UniProt:Q9HB71 CYBP			0.527	2
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.527	3
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.527	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.527	2
UniProt:P51817 PRKX	1	PRKX [nucleoplasm] (R-HSA-3222308)	0.527	2
UniProt:Q96EK5 KBP			0.527	2
UniProt:Q8IVD9 NUDC3			0.527	3
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.527	2
UniProt:Q9UJA5 TRMT6	1	TRMT6 [nucleoplasm] (R-HSA-6783485)	0.527	2
UniProt:Q5TCX8 M3K21			0.527	2
UniProt:Q6NSI4 RADX			0.527	2
UniProt:O75190 DNAJB6	2	DNAJB6 [cytosol] (R-HSA-5252014) DNAJB6 [nucleoplasm] (R-HSA-5255425)	0.527	2
UniProt:Q5MAI5 CDKL4			0.527	2
UniProt:O60346 PHLPP1	1	PHLPP1 [cytosol] (R-HSA-199421)	0.527	2
UniProt:P53671 LIMK2	2	p-T505-LIMK2 [cytosol] (R-HSA-419711) LIMK2 [cytosol] (R-HSA-419171)	0.527	2
UniProt:Q00526 CDK3			0.527	2
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.527	2
UniProt:Q96RR4 CAMKK2	4	CAMKK2 [cytosol] (R-HSA-9619231) p-CAMKK2 [cytosol] (R-HSA-9619358) CAMKK2 [nucleoplasm] (R-HSA-5336483) p-CAMKK2 [nucleoplasm] (R-HSA-9618968)	0.527	3
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.527	3
UniProt:P06737 PYGL	5	PXLP-PYGL [secretory granule lumen] (R-HSA-6801509) PXLP-PYGL [extracellular region] (R-HSA-6801551) PXLP-PYGL [ficolin-1-rich granule lumen] (R-HSA-6801505) PXLP-PYGL [cytosol] (R-HSA-71580) PXLP-p-S15-PYGL [cytosol] (R-HSA-71585)	0.527	2
UniProt:O95801 TTC4			0.527	2
UniProt:Q8TDR2 STK35			0.527	2
UniProt:Q9Y266 NUDC	4	NUDC [cytosol] (R-HSA-377731) NUDC [nucleoplasm] (R-HSA-156716) p-S274,S326-NUDC [cytosol] (R-HSA-156702) p-S274,S326-NUDC [spindle] (R-HSA-9648125)	0.527	2
UniProt:Q14004 CDK13	3	CDK13 [nucleoplasm] (R-HSA-6797014) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374) CDK13 [extracellular region] (R-HSA-6806442)	0.527	3
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.527	2
UniProt:Q13555 CAMK2G	5	p-T287-CAMK2G [plasma membrane] (R-HSA-432797) p-T287-CAMK2G [endocytic vesicle membrane] (R-HSA-417014) p-T287-CAMK2G [nucleoplasm] (R-HSA-444781) CAMK2G [cytosol] (R-HSA-9611358) p-T287-CAMK2G [cytosol] (R-HSA-445369)	0.527	2
UniProt:Q8N165 PDK1L			0.527	2
UniProt:O95433 AHSA1			0.527	4
UniProt:P51957 NEK4			0.527	2
UniProt:P21127 CDK11B	1	CDK11B [cytosol] (R-HSA-380451)	0.527	2
UniProt:Q9P0Z9 PIPOX	2	PIPOX [cytosol] (R-HSA-9033136) PIPOX [peroxisomal matrix] (R-HSA-452911)	0.527	3
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	3
UniProt:Q9BQI3 EIF2AK1	3	p-T-EIF2AK1 [cytosol] (R-HSA-9648892) p-T,T486,T488-EIF2AK1 [cytosol] (R-HSA-9648894) EIF2AK1 [cytosol] (R-HSA-9840382)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:Q9H3Y6 SRMS	1	SRMS [cytosol] (R-HSA-3902520)	0.527	3
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.527	2
UniProt:Q00534 CDK6	3	CDK6 [cytosol] (R-HSA-68336) CDK6 [nucleoplasm] (R-HSA-141283) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.527	2
UniProt:Q9WMX2-PRO_0000037552			0.499	4

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