Reactome | AcK-TUBA1B [cytosol]

AcK-TUBA1B [cytosol]

Stable Identifier

R-HSA-5618285

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tubulin K-alpha-1, alpha K tubulin-1

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - ATAT acetylates microtubules (Homo sapiens)
    - acetylated microtubule [cytosol] (Homo sapiens)
      - acetylated microtubule protofilament [cytosol] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Ac K40 alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        acetylated alpha tubulin [cytosol] (Homo sapiens)
        
        AcK-TUBA1B [cytosol] (Homo sapiens)
  - HDAC6 deacetylates microtubules (Homo sapiens)
    - acetylated microtubule [cytosol] (Homo sapiens)
      - acetylated microtubule protofilament [cytosol] (Homo sapiens)
        
        Ac K40 alpha tubulin-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Ac K40 alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        acetylated alpha tubulin [cytosol] (Homo sapiens)
        
        AcK-TUBA1B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68363 TUBA1B

Gene Names

TUBA1B

Chain

chain:1-451, chain:1-450

Reference Genes

BioGPS Gene:10376 TUBA1B

COSMIC (genes):TUBA1B TUBA1B

CTD Gene:10376 TUBA1B

dbSNP Gene:10376 TUBA1B

ENSEMBL:ENSG00000123416 TUBA1B

ENSEMBL_homo_sapiens_GENE:ENSG00000123416.15 TUBA1B

HGNC:18809 TUBA1B

KEGG Gene (Homo sapiens):10376 TUBA1B

Monarch:10376 TUBA1B

NCBI Gene:10376 TUBA1B

OMIM:602530 TUBA1B

UCSC:P68363 TUBA1B

Reference Transcript

RefSeq:NM_006082.2 TUBA1B

Other Identifiers

10376

11744345_x_at

11756979_x_at

201090_PM_x_at

201090_x_at

209251_PM_x_at

211058_PM_x_at

211058_x_at

211072_PM_x_at

211072_x_at

211750_PM_x_at

212639_PM_x_at

212639_x_at

213646_PM_x_at

213646_x_at

2872626

32272_at

3344233

3344241

3344242

3413815

3413819

3413821

3413822

3413824

3453738

3453739

3453740

3453741

3453742

3453743

3453745

3453746

3453747

3453748

3453749

3453753

3453841

3453845

3453846

3640627

59760_f_at

7963046

GO:0000166

GO:0000226

GO:0000278

GO:0003723

GO:0003725

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0005881

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0030705

GO:0031625

GO:0043226

GO:0051301

GO:0071353

HMNXSV003034622

Hs.240615.2.S1_3p_x_at

Hs.272897.2.S1_3p_x_at

ILMN_1742167

ILMN_1800261

TC12000363.hg

TC12001470.hg

TC12002866.hg

g13623540_3p_x_at

g5174476_3p_x_at

Participates

as a candidate of

acetylated alpha tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

Ac K40 TUBA1B [axonemal microtubule]

TUBA1B folding intermediate [cytosol]

TUBA1B unfolded [cytosol]

L-isoglutamyl polyglycyl-TUBA1B [cytosol]

Polyglutamyl-TUBA1B [cytosol]

TUBA1B(1-450) [cytosol]

TUBA1B [axonemal microtubule]

TUBA1B [cytosol]

Inferred To

TUBA1B [cytosol] (Canis familiaris)

tuba1b [cytosol] (Xenopus tropicalis)

Homologues of AcK-TUBA1B [cytosol] (Dictyostelium discoideum)

Homologues of AcK-TUBA1B [cytosol] (Plasmodium falciparum)

AcK-TUBA1B [cytosol] (Dictyostelium discoideum)

AcK-TUBA1B [cytosol] (Mus musculus)

AcK-TUBA1B [cytosol] (Plasmodium falciparum)

AcK-TUBA1B [cytosol] (Rattus norvegicus)

AcK-TUBA1B [cytosol] (Sus scrofa)

Modified Residues

Name

N6-acetyl-L-lysine at 40

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_006073.2

OpenTargets

ENSG00000123416

HPA

ENSG00000123416-TUBA1B

GeneCards

P68363

Ensembl

ENST00000336023, ENSG00000123416, ENSP00000336799

PRO

P68363

Pharos - Targets

P68363

HMDB Protein

HMDBP08594

PDB

7LXB, 7Z6S, 5IJ9, 6QUS, 7SJ9, 7SJ8, 5IJ0, 2E4H, 7PJF, 8VA2, 6J4V, 6J8O, 8V2I, 7SJ7, 6QVJ, 7M20, 8VRK, 6E7C, 7ZCW, 6E7B, 6QVE, 5N5N, 8VRJ, 6I2I, 6QUY, 6S8L, 7M18, 7SJA, 8VT7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.643	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.643	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2

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