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Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Stable Identifier
R-HSA-5619107
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (Homo sapiens)
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The nuclear pore complex (NPC) trafficks cargo across the nuclear membrane. Nucleoprotein TPR functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. The complex glucokinase (GCK1) and glucokinase regulatory protein (GKRP) can be translocated to the nucleus via the NPC. Defects in TPR may confer susceptibility towards thyroid papillary carcinona (TPC; MIM:18850), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue (Vriens et al. 2009, Bonora et al. 2010).
Literature References
PubMed ID
Title
Journal
Year
20628519
Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies
Romeo, G
,
Bonora, E
,
Tallini, G
J Oncol
2010
20001717
Clinical features and genetic predisposition to hereditary nonmedullary thyroid cancer
Vriens, MR
,
Suh, I
,
Kebebew, E
,
Moses, W
Thyroid
2009
Participants
Events
Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm
(Homo sapiens)
Participates
as an event of
SLC transporter disorders (Homo sapiens)
Disease
Name
Identifier
Synonyms
papillary carcinoma
DOID:3113
Papillary carcinoma (morphologic abnormality), Papillary carcinoma, Papillary carcinoma NOS (morphologic abnormality)
Authored
Jassal, B (2014-08-22)
Reviewed
Broer, S (2015-08-04)
Created
Jassal, B (2014-08-22)
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