Reactome | ASAP1 [cytosol]

ASAP1 [cytosol]

Stable Identifier

R-HSA-5620905

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DDEF1

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - VxPx cargo-targeting to cilium (Homo sapiens)
      - ASAP1 dimer binds membrane proteins (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - Cargo-carrying vesicles bud from the TGN (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
        
        exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)
      - VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)
        
        exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
        
        ASAP1 dimer [cytosol] (Homo sapiens)
        
        ASAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9ULH1 ASAP1

Gene Names

ASAP1, DDEF1, KIAA1249, PAG2

Chain

chain:1-1129

Reference Genes

BioGPS Gene:50807 ASAP1

COSMIC (genes):ASAP1 ASAP1

CTD Gene:50807 ASAP1

dbSNP Gene:50807 ASAP1

ENSEMBL:ENSG00000153317 ASAP1

HGNC:2720 ASAP1

KEGG:hsa:50807 ASAP1

Monarch:50807 ASAP1

NCBI Gene:50807 ASAP1

OMIM:605953 ASAP1

UCSC:Q9ULH1 ASAP1

Reference Transcript

Other Identifiers

11717281_a_at

11717282_at

11717283_a_at

11755032_s_at

17081162

221039_PM_s_at

221039_s_at

224790_PM_at

224790_at

224791_PM_at

224791_at

224796_PM_at

224796_at

236533_PM_at

236533_at

3153427

3153429

3153430

3153431

3153432

3153433

3153434

3153435

3153438

3153440

3153444

3153447

3153453

3153454

3153468

3153469

3153471

3153472

3153473

3153475

3153476

3153477

3153478

3153481

3153482

3153483

3153485

3153486

3153487

3153489

3153503

3153504

3153505

3153506

3153507

3153508

3153514

3153515

3153527

3153528

3153529

3153530

3153531

3153532

3153535

3153544

3153545

3153549

3153556

3153603

3153614

3153616

3153617

3153621

3153622

3153628

3153629

3153644

48803_at

50807

60030_at

69516_at

8152867

A_21_P0005976

A_23_P216278

A_23_P44831

A_23_P71526

A_33_P3775007

GE53850

GE633089

GE82388

GO:0000139

GO:0002102

GO:0005096

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0008270

GO:0016020

GO:0030030

GO:0032588

GO:0034451

GO:0043226

GO:0043547

GO:0044782

GO:0045296

GO:0046872

GO:0060271

GO:0061512

GO:0098772

GO:1903527

HMNXSV003040355

HMNXSV003043886

Hs.10669.1.S1_3p_at

Hs.10669.1.S2_3p_at

Hs.10669.1.S3_3p_at

Hs.199057.0.A1_3p_at

ILMN_1690963

ILMN_2233366

PH_hs_0024401

PH_hs_0036086

RNA147148|p0252_imsncRNA402

TC08001641.hg

TC08002532.hg

g8923867_3p_a_at

p24051

Participates

as a component of

ASAP1 dimer [cytosol] (Homo sapiens)

Inferred To

ASAP1 [cytosol] (Bos taurus)

ASAP1 [cytosol] (Canis familiaris)

ASAP1 [cytosol] (Gallus gallus)

ASAP1 [cytosol] (Sus scrofa)

Ghost homologue of ASAP1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of ASAP1 [cytosol] (Danio rerio)

Ghost homologue of ASAP1 [cytosol] (Xenopus tropicalis)

Asap [cytosol] (Drosophila melanogaster)

Asap1 [cytosol] (Mus musculus)

Asap1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_006716626.1, XP_011515354.1, XP_005250982.1, NP_060952.2, NP_001349853.1, XP_047277756.1, NP_001234925.1, XP_047277755.1

OpenTargets

ENSG00000153317

ENSEMBL

ENSP00000429900, ENST00000518721, ENSG00000153317

HPA

ENSG00000153317-ASAP1

GeneCards

ASAP1

PRO

Q9ULH1

Pharos - Targets

Q9ULH1

GlyGen

Q9ULH1

PDB

2ED1, 2DA0, 2RQT, 2RQU, 2D1X

HMDB Protein

HMDBP10723

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.916	13
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.885	14
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.765	7
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.702	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.669	5
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.643	3
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.609	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276)	0.609	3
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.609	6
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	3
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122)	0.524	2