HOXB1 activates HOXA2 expression

Stable Identifier
R-HSA-5621010
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HOXB1 activates HOXA2 expression
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As inferred from mouse homologs, HOXA2 expression is driven by HOXB1 in rhombomere 4 (r4) and EGR2 (KROX20) in r3 and r5. HOXB1 together with PBX and PREP/MEIS cofactors bind an element in the intron of HOXA2. (HOXA2 is the only HOX gene active in r2. An unknown activator, possibly a transcription factor of the SOX family, may be involved in expression in r2.)
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Inferred From
Hoxb1 activates Hoxa2 expression (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-28)
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