Reactome | LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG

LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG

Stable Identifier

R-HSA-5621355

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG

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Ligation of CLEC6A (C-type lectin domain family 6 member A/Dectin-2) and CLEC4E (Mincle) with their appropriate ligands trigger the tyrosine phosphorylation of the immune receptor tyrosine-based activation motif (ITAM) in the cytoplasmic tail of FCER1G chain. Tyrosine Y65 and Y76 in the ITAM are phosphorylated and this phosphorylation is mediated by Src kinases Lyn and Fyn (Sato et al. 2006, Yamasaki et al. 2008, Quek et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
17050534	Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses Yang, XL, Underhill, D, Kimberly, RP, Chung, JS, Sato, K, Luby-Phelps, K, Ariizumi, K, Cruz, PD, Wu, J, Yudate, T	J. Biol. Chem.	2006
11110698	Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway Watson, SP, Dunn, AR, Hibbs, ML, Barnes, M, Knight, G, Pasquet, JM, Cornall, R, Hers, I, Quek, LS, Lowell, CA	Blood	2000
18776906	Mincle is an ITAM-coupled activating receptor that senses damaged cells Sakuma, M, Ogata, K, Hara, H, Saito, T, Yamasaki, S, Ishikawa, E	Nat. Immunol.	2008