SYK binds to p-Y65,Y76-FCER1G

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SYK is a cytoplasmic tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. Tyrosine phosphorylation of the FCER1G ITAM recruits SYK and initiates a signaling cascade, leading to the activation of transcription factors such as NF-kB via CARD9-BCL10-MALT1 (Kerscher et al. 2013).

Literature References
PubMed ID Title Journal Year
18776906 Mincle is an ITAM-coupled activating receptor that senses damaged cells

Yamasaki, S, Ishikawa, E, Sakuma, M, Hara, H, Ogata, K, Saito, T

Nat. Immunol. 2008
17050534 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses

Sato, K, Yang, XL, Yudate, T, Chung, JS, Wu, J, Luby-Phelps, K, Kimberly, RP, Underhill, D, Cruz, PD, Ariizumi, K

J. Biol. Chem. 2006
Orthologous Events
Cite Us!