Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EXOC3 [cytosol]
Stable Identifier
R-HSA-5623379
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SEC6, SEC6L1
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC3 [cytosol] (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC3 [cytosol] (Homo sapiens)
VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60645 EXOC3
Gene Names
EXOC3, SEC6, SEC6L1
Chain
chain:1-745
Reference Genes
BioGPS Gene:11336 EXOC3
COSMIC (genes):EXOC3 EXOC3
CTD Gene:11336 EXOC3
dbSNP Gene:11336 EXOC3
ENSEMBL:ENSG00000180104 EXOC3
ENSEMBL_homo_sapiens_GENE:ENSG00000180104.16 EXOC3
HGNC:30378 EXOC3
KEGG Gene (Homo sapiens):11336 EXOC3
Monarch:11336 EXOC3
NCBI Gene:11336 EXOC3
OMIM:608186 EXOC3
UCSC:O60645 EXOC3
Reference Transcript
RefSeq:NM_007277.4 EXOC3
RefSeq:XM_017009003.1 EXOC3
RefSeq:XM_017009004.1 EXOC3
Other Identifiers
11336
11716926_a_at
212630_PM_at
212630_at
2798680
2798681
2798682
2798683
2798685
2798686
2798688
2798689
2798690
2798691
2798694
2798695
2798698
2798704
2798705
2798707
2798708
2798709
2798710
2798711
2798712
2798713
2798714
2798715
2798716
37597_s_at
8104201
A_23_P93046
GE54509
GO:0000145
GO:0000149
GO:0000278
GO:0000281
GO:0000910
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006887
GO:0006904
GO:0015031
GO:0016192
GO:0030426
GO:0030496
GO:0030667
GO:0031410
GO:0042734
GO:0042995
GO:0043005
GO:0043226
GO:0045296
GO:0048471
GO:0051601
GO:0061024
GO:0090148
GO:0090522
HMNXSV003048862
Hs.8088.0.A1_3p_at
ILMN_1789419
PH_hs_0030371
PH_hs_0036049
TC05000006.hg
Participates
as a component of
exocyst complex [cytosol] (Homo sapiens)
Other forms of this molecule
EXOC3 [secretory granule membrane]
Inferred To
exoc3 [cytosol]
(Xenopus tropicalis)
sec-6 [cytosol]
(Caenorhabditis elegans)
Sec6 [cytosol]
(Drosophila melanogaster)
Exoc3 [cytosol]
(Mus musculus)
Exoc3 [cytosol]
(Rattus norvegicus)
EXOC3 [cytosol]
(Bos taurus)
EXOC3 [cytosol]
(Canis familiaris)
EXOC3 [cytosol]
(Gallus gallus)
EXOC3 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016864492.1
,
NP_009208.2
,
XP_016864493.1
OpenTargets
ENSG00000180104
HPA
ENSG00000180104-EXOC3
GeneCards
O60645
Ensembl
ENSG00000180104
,
ENSP00000425587
,
ENST00000315013
,
ENSP00000323377
,
ENST00000512944
PRO
O60645
Pharos - Targets
O60645
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.725
6
UniProt:Q96KP1 EXOC2
2
EXOC2 [plasma membrane]
(R-HSA-264887)
EXOC2 [cytosol]
(R-HSA-5623376)
0.725
6
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.725
5
UniProt:Q9UPT5 EXOC7
2
EXOC7 [plasma membrane]
(R-HSA-2872288)
EXOC7 [cytosol]
(R-HSA-5623386)
0.638
4
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.638
4
UniProt:Q8IYI6 EXOC8
2
EXOC8 [plasma membrane]
(R-HSA-264948)
EXOC8 [cytosol]
(R-HSA-5623388)
0.638
4
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.638
5
UniProt:Q96IK5 GMCL1
0.556
3
UniProt:Q9BZL4 PP12C
0.556
3
UniProt:A1L4K1 FSD2
0.556
3
UniProt:Q96NL6 SCLT1
1
SCLT1 [cytosol]
(R-HSA-5620935)
0.527
2
UniProt:P0DJD1 RGPD2
0.527
2
UniProt:Q9BQ69 MACD1
0.527
2
UniProt:Q9BQD3 KXDL1
0.527
2
UniProt:Q99666 RGPD5
0.527
2
UniProt:Q8IWJ2 GCC2
3
GCC2 [cytosol]
(R-HSA-6813880)
GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713455)
GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713458)
0.527
3
UniProt:Q8WXW3 PIBF1
0.527
2
UniProt:P27930 IL1R2
1
IL1R2 [plasma membrane]
(R-HSA-197598)
0.527
4
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.527
2
UniProt:Q15643 TRIP11
4
TRIP11 [transport vesicle]
(R-HSA-8847847)
TRIP11 [Golgi membrane]
(R-HSA-5617602)
TRIP11(2-1724)-FLT3(594-993) fusion [cytosol]
(R-HSA-9703323)
TRIP11(2-1724)-p-4Y-FLT3(594-993) fusion [cytosol]
(R-HSA-9703304)
0.527
3
UniProt:Q9Y496 KIF3A
3
KIF3A [cilium]
(R-HSA-5610394)
KIF3A [cytosol]
(R-HSA-984767)
KIF3A [ciliary tip]
(R-HSA-5625377)
0.527
3
UniProt:Q13563 PKD2
3
PKD2 [ciliary membrane]
(R-HSA-5623409)
PKD2 [Golgi membrane]
(R-HSA-5623393)
PKD2 [Golgi-associated vesicle membrane]
(R-HSA-5623411)
0.527
2
UniProt:Q9H0B6 KLC2
1
KLC2 [cytosol]
(R-HSA-983191)
0.527
2
UniProt:Q9Y2D4 EXC6B
0.508
3
UniProt:Q13445 TMED1
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text