Reactome | RAB8A [cytosol]

RAB8A [cytosol]

Stable Identifier

R-HSA-5623399

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61006 RAB8A

Gene Names

RAB8A, MEL, RAB8

Chain

chain:1-204, propeptide:205-207

Reference Genes

BioGPS Gene:4218 RAB8A

COSMIC (genes):RAB8A RAB8A

CTD Gene:4218 RAB8A

dbSNP Gene:4218 RAB8A

ENSEMBL:ENSG00000167461 RAB8A

HGNC:7007 RAB8A

KEGG:hsa:4218 RAB8A

Monarch:4218 RAB8A

NCBI Gene:4218 RAB8A

OMIM:165040 RAB8A

UCSC:P61006 RAB8A

Reference Transcript

RefSeq:NM_005370.4 RAB8A

Other Identifiers

11742706_s_at

16859270

208819_PM_at

208819_at

35339_at

35340_at

3823555

3823556

3823557

3823558

3823559

3823560

3823561

3823563

3823564

3823567

3823568

3823569

3823570

3823575

3823576

3823577

3823578

3823579

3823580

3823582

4218

43190_at

8026520

A_14_P111306

A_23_P164752

A_24_P190424

A_33_P3320127

GE62175

GO:0000139

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005737

GO:0005768

GO:0005794

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0006886

GO:0006887

GO:0006904

GO:0006914

GO:0007030

GO:0007409

GO:0008021

GO:0008092

GO:0009306

GO:0010008

GO:0010506

GO:0015031

GO:0016192

GO:0016787

GO:0019003

GO:0019901

GO:0030030

GO:0030140

GO:0030425

GO:0030496

GO:0030670

GO:0031267

GO:0031410

GO:0031489

GO:0032456

GO:0032588

GO:0032869

GO:0032880

GO:0036064

GO:0043005

GO:0043025

GO:0043197

GO:0043226

GO:0044782

GO:0045202

GO:0045335

GO:0048169

GO:0048210

GO:0051223

GO:0055037

GO:0055038

GO:0060170

GO:0060271

GO:0061024

GO:0061512

GO:0070062

GO:0072659

GO:0097546

GO:0097730

GO:0098887

GO:0098969

GO:0098978

GO:0099003

GO:1990782

HMNXSV003049034

ILMN_1760858

PH_hs_0000602

TC19000317.hg

TC19002017.hg

X56741_at

g12804236_3p_at

Participates

as a component of

as a member of

RABs [cytosol] (Homo sapiens)

Other forms of this molecule

RAB8A [Golgi membrane]

GGC-RAB8A [cytosol]

GGC-RAB8A [trans-Golgi network membrane]

RAB8A [recycling endosome membrane]

GGC-RAB8A [cytoplasmic vesicle membrane]

Inferred To

rab8a [cytosol] (Danio rerio)

rab8a [cytosol] (Xenopus tropicalis)

Homologues of RAB8A [cytosol] (Caenorhabditis elegans)

Homologues of RAB8A [cytosol] (Dictyostelium discoideum)

Homologues of RAB8A [cytosol] (Schizosaccharomyces pombe)

rab-8 [cytosol] (Caenorhabditis elegans)

rabr-1 [cytosol] (Caenorhabditis elegans)

Rab8 [cytosol] (Drosophila melanogaster)

RAB8A [cytosol] (Bos taurus)

RAB8A [cytosol] (Canis familiaris)

RAB8A [cytosol] (Dictyostelium discoideum)

RAB8A [cytosol] (Gallus gallus)

RAB8A [cytosol] (Mus musculus)

RAB8A [cytosol] (Rattus norvegicus)

RAB8A [cytosol] (Saccharomyces cerevisiae)

RAB8A [cytosol] (Schizosaccharomyces pombe)

RAB8A [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005361.2

OpenTargets

ENSG00000167461

ENSEMBL

ENST00000586682, ENSP00000300935, ENST00000300935, ENSP00000467501

IntEnz

3.6.5.2

HPA

ENSG00000167461-RAB8A

PRO

P61006

Pharos - Targets

P61006

GlyGen

P61006

PDB

6STG, 3QBT, 4LHZ, 7BWT, 3TNF, 4LHW, 5SZI, 6RIR, 4LHV, 7LWB, 4LHY, 4LHX, 6YX5, 6WHE, 6SQ2, 4LI0, 6STF, 6ZSI, 6ZSJ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
GDP [ChEBI:17552]	7	GDP [lysosomal membrane] (R-ALL-9628545) GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [cilium] (R-ALL-5617810) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [nucleoplasm] (R-ALL-111349) GDP [plasma membrane] (R-ALL-114549) GDP [endoplasmic reticulum lumen] (R-ALL-1467290)	0.819	24
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.781	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.77	9
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.676	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.633	4
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.623	3
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.527	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	2
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.508	2
UniProt:Q8NFJ9 BBS1	1	BBS1 [cytosol] (R-HSA-5617640)	0.508	2
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.508	2