Reactome | RAB3IP and RAB8A bind to the ciliary targeting complex

RAB3IP and RAB8A bind to the ciliary targeting complex

Stable Identifier

R-HSA-5623519

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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RAB3IP and RAB8A bind to the ciliary targeting complex

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RAB8A is another small GTPase that is required for ciliogenesis. RAB8A is recruited to the ciliary targeting complex at the trans-Golgi network (TGN) through interactions of the RAB8A guanine nucleotide exchange factor (GEF) RAB3IP (also known as RABIN8) with ASAP1 and RAB11 (Wang et al, 2012; Westlake et al, 2011; Feng et al, 2012; reviewed in Deretic, 2013). RAB8A is recruited in the inactive GDP bound form, and is activated at the TGN by RAB3IP in a RAB11A-dependent fashion (Hatulla et al, 2002; Knodler et al, 2010; Westlake et al, 2012; Wang et al, 2012; Feng et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
20308558	Coordination of Rab8 and Rab11 in primary ciliogenesis Knödler, A, Feng, S, Zhang, J, Zhang, X, Das, A, Peränen, J, Guo, W	Proc. Natl. Acad. Sci. U.S.A.	2010
12221131	A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport Hattula, K, Furuhjelm, J, Arffman, A, Peränen, J	Mol. Biol. Cell	2002
21273506	Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome Westlake, CJ, Baye, LM, Nachury, MV, Wright, KJ, Ervin, KE, Phu, L, Chalouni, C, Beck, JS, Kirkpatrick, DS, Slusarski, DC, Sheffield, VC, Scheller, RH, Jackson, PK	Proc. Natl. Acad. Sci. U.S.A.	2011
22433857	A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis Feng, S, Knödler, A, Ren, J, Zhang, J, Zhang, X, Hong, Y, Huang, S, Peränen, J, Guo, W	J. Biol. Chem.	2012
22983554	The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting Wang, J, Morita, Y, Mazelova, J, Deretic, D	EMBO J.	2012
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013