Reactome | RAB3IP stimulates nucleotide exchange on RAB8A

RAB3IP stimulates nucleotide exchange on RAB8A

Stable Identifier

R-HSA-5623521

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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RAB3IP stimulates nucleotide exchange on RAB8A

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Once recruited to the ciliary targeting complex, RAB3IP/RABIN8 stimulates nucleotide exchange on RAB8A. Activated RAB8A is required for ciliogenesis and plays a role in mediating vesicle docking at the basal body, providing both lipid and protein content to the emerging cilium (Hattula et al, 2002; Knodler et al, 2010; Nachury et al, 2007; Wang et al, 2012; Westlake et al, 2011; Yoshimura et al, 2007; reviewed in Deretic, 2013; Sung and Leroux, 2013).

Literature References

PubMed ID	Title	Journal	Year
24296415	The roles of evolutionarily conserved functional modules in cilia-related trafficking Sung, CH, Leroux, MR	Nat. Cell Biol.	2013
17646400	Functional dissection of Rab GTPases involved in primary cilium formation Yoshimura, S, Egerer, J, Fuchs, E, Haas, AK, Barr, FA	J. Cell Biol.	2007
20308558	Coordination of Rab8 and Rab11 in primary ciliogenesis Knödler, A, Feng, S, Zhang, J, Zhang, X, Das, A, Peränen, J, Guo, W	Proc. Natl. Acad. Sci. U.S.A.	2010
12221131	A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport Hattula, K, Furuhjelm, J, Arffman, A, Peränen, J	Mol. Biol. Cell	2002
21273506	Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome Westlake, CJ, Baye, LM, Nachury, MV, Wright, KJ, Ervin, KE, Phu, L, Chalouni, C, Beck, JS, Kirkpatrick, DS, Slusarski, DC, Sheffield, VC, Scheller, RH, Jackson, PK	Proc. Natl. Acad. Sci. U.S.A.	2011
22983554	The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting Wang, J, Morita, Y, Mazelova, J, Deretic, D	EMBO J.	2012
17574030	A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK	Cell	2007
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013

Participants

Input

Output

Participates

as an event of

VxPx cargo-targeting to cilium (Homo sapiens)

Catalyst Activity

guanyl-nucleotide exchange factor activity of RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane]

Physical Entity

RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)

Activity

guanyl-nucleotide exchange factor activity (GO:0005085)

Orthologous Events

RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)

RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)

RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)

RAB3IP stimulates nucleotide exchange on RAB8A (Drosophila melanogaster)

RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)

RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)

RAB3IP stimulates nucleotide exchange on RAB8A (Rattus norvegicus)