Reactome | PKN3 [cytosol]

PKN3 [cytosol]

Stable Identifier

R-HSA-5623611

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase N3, PKNBETA, PRK3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q6P5Z2 PKN3

Gene Names

PKN3, PKNBETA

Chain

chain:1-889

Reference Genes

BioGPS Gene:29941 PKN3

COSMIC (genes):PKN3 PKN3

CTD Gene:29941 PKN3

dbSNP Gene:29941 PKN3

ENSEMBL:ENSG00000160447 PKN3

HGNC:17999 PKN3

KEGG:hsa:29941 PKN3

Monarch:29941 PKN3

NCBI Gene:29941 PKN3

OMIM:610714 PKN3

UCSC:Q6P5Z2 PKN3

Reference Transcript

RefSeq:NM_013355.4 PKN3

Other Identifiers

11722938_a_at

11722939_a_at

17089819

226299_PM_at

226299_at

29941

3190684

3190685

3190686

3190688

3190689

3190690

3190691

3190692

3190693

3190694

3190696

3190697

3190698

3190699

3190700

3190701

3190702

3190705

3190707

3190708

3190709

3190710

3190711

3190713

3190714

3190715

3190716

3190717

3190718

3190719

55643_at

64669_at

8158380

85649_at

A_23_P258982

A_33_P3220202

GE53516

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0006468

GO:0007165

GO:0010631

GO:0016740

GO:0031267

GO:0035556

GO:0043226

GO:0048471

GO:0048870

GO:0106310

GO:0140096

HMNXSV003009119

Hs.44101.0.S1_3p_at

ILMN_1797184

PH_hs_0028145

TC09000699.hg

Participates

as a member of

as a candidate of

PKN1-3 [cytosol] (Homo sapiens)

Other forms of this molecule

p-T718-PKN3 [cytosol]

Inferred To

Homologues of PKN3 [cytosol] (Danio rerio)

Homologues of PKN3 [cytosol] (Dictyostelium discoideum)

Homologues of PKN3 [cytosol] (Schizosaccharomyces pombe)

PKN3 [cytosol] (Bos taurus)

PKN3 [cytosol] (Caenorhabditis elegans)

PKN3 [cytosol] (Canis familiaris)

PKN3 [cytosol] (Danio rerio)

PKN3 [cytosol] (Dictyostelium discoideum)

PKN3 [cytosol] (Drosophila melanogaster)

PKN3 [cytosol] (Gallus gallus)

PKN3 [cytosol] (Mus musculus)

PKN3 [cytosol] (Saccharomyces cerevisiae)

PKN3 [cytosol] (Schizosaccharomyces pombe)

PKN3 [cytosol] (Sus scrofa)

PKN3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_037487.2

Guide to Pharmacology - Targets

1522

ENSEMBL

ENST00000291906, ENSP00000291906

OpenTargets

ENSG00000160447

IntEnz

2.7.11.13

HPA

ENSG00000160447-PKN3

PRO

Q6P5Z2

Pharos - Targets

Q6P5Z2

GlyGen

Q6P5Z2

HMDB Protein

HMDBP09509

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A1A4S6 ARHGAP10	1	ARHGAP10 [cytosol] (R-HSA-195125)	0.681	5
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.643	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q22038	16	RHOD [mitochondrial outer membrane] (R-CEL-9693212) RHOD [cytosol] (R-CEL-194848) RHOD [plasma membrane] (R-CEL-194889) RHOD [Golgi membrane] (R-CEL-9693236) RHOA [endoplasmic reticulum membrane] (R-CEL-5672082) RHOF [plasma membrane] (R-CEL-194921) RHOF [secretory granule membrane] (R-CEL-6804978) RHOA [secretory granule membrane] (R-CEL-6804980) RHOA [ficolin-1-rich granule membrane] (R-CEL-6804971) RHOB [endosome membrane] (R-CEL-5666064) RHOD [endosome membrane] (R-CEL-5666090) RHOB [cytosol] (R-CEL-194855) RHOA [cytosol] (R-CEL-194866) RHOA [cell junction] (R-CEL-2134503) RHOA [plasma membrane] (R-CEL-194510) RHOB [plasma membrane] (R-CEL-194891)	0.544	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.527	3

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