RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

Stable Identifier
R-HSA-5623632
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Binding of PKN1, PKN2 or PKN3 to any of the RHO GTP-ases RHOA, RHOB, RHOC or RAC1 enables PKN1, PKN2 and PKN3 to interact with PIP3-activated kinase PDPK1, through the formation of ternary complexes (Flynn et al. 2000, Torbett et al. 2003).
Literature References
PubMed ID Title Journal Year
12783890 Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1

Casamassima, A, Parker, PJ, Torbett, NE

J. Biol. Chem. 2003
10753910 Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

Flynn, P, Casamassima, A, Parker, PJ, Mellor, H

J. Biol. Chem. 2000
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