Reactome | p-T774-PKN1 [cytosol]

p-T774-PKN1 [cytosol]

Stable Identifier

R-HSA-5623651

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T774-PRK1

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External Reference Information

External Reference

UniProt:Q16512 PKN1

Gene Names

PKN1, PAK1, PKN, PRK1, PRKCL1

Chain

initiator methionine:, chain:2-942

Reference Genes

BioGPS Gene:5585 PKN1

COSMIC (genes):PAK1 PKN1

COSMIC (genes):PKN1 PKN1

CTD Gene:5585 PKN1

dbSNP Gene:5585 PKN1

ENSEMBL:ENSG00000123143 PKN1

HGNC:9405 PKN1

KEGG:hsa:5585 PKN1

Monarch:5585 PKN1

NCBI Gene:5585 PKN1

OMIM:601032 PKN1

UCSC:Q16512 PKN1

Reference Transcript

Other Identifiers

11733072_a_at

16858991

175_s_at

202161_PM_at

202161_at

3822724

3822725

3822726

3822728

3822730

3822731

3822732

3822733

3822734

3822735

3822738

3822739

3822740

3822744

3822745

3822746

3822747

3822749

3822752

3822753

3822754

3822755

3822756

3822757

3822758

3822759

3822760

3822761

3822762

3822763

3822764

3822765

3822766

3822768

3822770

3822771

3822772

3822773

3822775

3822776

3822778

3822780

3822781

5585

8026315

80688_at

A_14_P119416

A_14_P134902

A_23_P67271

GE59091

GO:0001782

GO:0001783

GO:0001933

GO:0002376

GO:0002634

GO:0002637

GO:0003014

GO:0003682

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0005080

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0006468

GO:0006972

GO:0007165

GO:0010631

GO:0012501

GO:0016740

GO:0030374

GO:0030496

GO:0030889

GO:0031267

GO:0031410

GO:0032154

GO:0032991

GO:0035402

GO:0035556

GO:0042393

GO:0042826

GO:0043226

GO:0043687

GO:0045893

GO:0048536

GO:0048856

GO:0048870

GO:0050681

GO:0060090

GO:0060765

GO:0106310

GO:0140096

GO:0140110

GO:2000145

ILMN_1662687

ILMN_2272120

ILMN_2367707

ILMN_2367710

PH_hs_0000335

TC19000257.hg

U33053_at

g4506072_3p_at

p8579

Participates

as a component of

as an input of

as a member of

p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] (Homo sapiens)

as an output of

p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)

Other forms of this molecule

PKN1 [cytosol]

p-T774-PKN1 [nucleoplasm]

Inferred To

Homologues of p-T774-PKN1 [cytosol] (Dictyostelium discoideum)

Homologues of p-T774-PKN1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T774-PKN1 [cytosol] (Bos taurus)

phospho-p-T774-PKN1 [cytosol] (Caenorhabditis elegans)

phospho-p-T774-PKN1 [cytosol] (Canis familiaris)

phospho-p-T774-PKN1 [cytosol] (Danio rerio)

phospho-p-T774-PKN1 [cytosol] (Dictyostelium discoideum)

phospho-p-T774-PKN1 [cytosol] (Drosophila melanogaster)

phospho-p-T774-PKN1 [cytosol] (Mus musculus)

phospho-p-T774-PKN1 [cytosol] (Rattus norvegicus)

phospho-p-T774-PKN1 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T774-PKN1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T774-PKN1 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 774

Coordinate

774

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_998725.1, NP_002732.3

ZINC - World Drugs

PKN1_HUMAN

Guide to Pharmacology - Targets

1520

OpenTargets

ENSG00000123143

ENSEMBL

ENSP00000242783, ENST00000342216, ENSP00000343325, ENST00000242783

ZINC - FDA approved

PKN1_HUMAN

ZINC - Substances

PKN1_HUMAN

ZINC - Biogenic

PKN1_HUMAN

ZINC target

Q16512

PRO

Q16512

GlyGen

Q16512

PDB

4OTD, 4NKG, 4OTI, 4OTH, 1CXZ, 2RMK, 4OTG, 1URF

ZINC - Investigational

PKN1_HUMAN

ZINC - Metabolites

PKN1_HUMAN

HPA

ENSG00000123143-PKN1

Pharos - Targets

Q16512

ZINC - Predictions - Purchasable

PKN1_HUMAN

HMDB Protein

HMDBP01531

Interactors (75)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.781	7
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q01850 CDR2			0.718	6
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q8N108-16 MIER1			0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:Q96QF0-7 RAB3IP			0.556	3
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
IntAct:EBI-22616457 CCSB ORF ID			0.556	3
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:Q96R06 SPAG5			0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q96M89-2 CCDC138			0.556	3
UniProt:Q8WU43 CB015			0.556	3
UniProt:Q9BV99 LRC61			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q8IWV8-2 Q8IWV82			0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q9H7B4 SMYD3	1	SMYD3 [nucleoplasm] (R-HSA-5637688)	0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q86T90 K1328			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:P26641 EEF1G	3	EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G [cytosol] (R-HSA-156925)	0.556	3
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q8IW40 CC103			0.556	3
UniProt:Q9BZW7 TSG10			0.556	3
UniProt:O76014 KRT37	1	KRT37 [cytosol] (R-HSA-6809614)	0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:Q9NZ72 STMN3			0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:P15289 ARSA	9	ARSA(448-507) [azurophil granule lumen] (R-HSA-6798775) ARSA(19-444) [azurophil granule lumen] (R-HSA-6798776) ARSA(448-507) [extracellular region] (R-HSA-6806249) ARSA(19-444) [extracellular region] (R-HSA-6806192) ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614334) ARSA(448-507) [endoplasmic reticulum lumen] (R-HSA-1614307) OxA-ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614359) OxA-ARSA(19-444) [lysosomal lumen] (R-HSA-508497) ARSA(448-507) [lysosomal lumen] (R-HSA-1606798)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	5
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q8IV13 CCNJL			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.556	3
UniProt:P54257 HAP1			0.556	3
UniProt:Q86XR8-3 CEP57			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q8WWB3 DYDC1			0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q6PJH3 Q6PJH3			0.556	3
UniProt:Q15834 CC85B			0.508	2

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