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p-T774-PKN1 [cytosol]
Stable Identifier
R-HSA-5623651
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-T774-PRK1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8ND90 PNMA1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)
p-T774-PKN1 [cytosol] (Homo sapiens)
p-T774-PKN1 binds CDC25C (Homo sapiens)
p-T774-PKN1 [cytosol] (Homo sapiens)
p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)
p-T774-PKN1 [cytosol] (Homo sapiens)
p-T774-PKN1 phosphorylates PPP1R14A (Homo sapiens)
p-T774-PKN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16512 PKN1
Gene Names
PKN1, PAK1, PKN, PRK1, PRKCL1
Chain
initiator methionine:, chain:2-942
Reference Genes
BioGPS Gene:5585 PKN1
COSMIC (genes):PKN1 PKN1
CTD Gene:5585 PKN1
dbSNP Gene:5585 PKN1
ENSEMBL:ENSG00000123143 PKN1
ENSEMBL_homo_sapiens_GENE:ENSG00000123143.13 PKN1
HGNC:9405 PKN1
KEGG Gene (Homo sapiens):5585 PKN1
Monarch:5585 PKN1
NCBI Gene:5585 PKN1
OMIM:601032 PKN1
UCSC:Q16512 PKN1
Reference Transcript
RefSeq:NM_213560.1 PKN1
RefSeq:NM_002741.3 PKN1
Other Identifiers
11733072_a_at
16858991
175_s_at
202161_PM_at
202161_at
3822725
3822726
3822730
3822731
3822732
3822733
3822738
3822739
3822740
3822744
3822745
3822746
3822747
3822749
3822753
3822754
3822755
3822757
3822758
3822759
3822760
3822761
3822762
3822763
3822764
3822766
3822770
3822771
5585
8026315
80688_at
A_23_P67271
GE59091
GO:0000166
GO:0001782
GO:0001783
GO:0001933
GO:0002376
GO:0002634
GO:0002637
GO:0003014
GO:0003682
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0005080
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0006972
GO:0007165
GO:0010631
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030374
GO:0030496
GO:0030889
GO:0031267
GO:0031410
GO:0032154
GO:0032991
GO:0035402
GO:0035556
GO:0036211
GO:0042393
GO:0042826
GO:0043226
GO:0043687
GO:0045893
GO:0048536
GO:0048856
GO:0048870
GO:0050681
GO:0060765
GO:0106310
GO:0140096
GO:0140110
GO:2000145
ILMN_1662687
ILMN_2272120
ILMN_2367707
ILMN_2367710
PH_hs_0000335
TC19000257.hg
U33053_at
g4506072_3p_at
Participates
as a component of
p-T774-PKN1:AR:Androgen [cytosol] (Homo sapiens)
p-T774-PKN1:CDC25C [cytosol] (Homo sapiens)
as an input of
Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)
p-T774-PKN1 binds CDC25C (Homo sapiens)
as a member of
p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] (Homo sapiens)
as an output of
p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)
Other forms of this molecule
p-T774-PKN1 [nucleoplasm]
PKN1 [cytosol]
Inferred To
Homologues of p-T774-PKN1 [cytosol]
(Dictyostelium discoideum)
Homologues of p-T774-PKN1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T774-PKN1 [cytosol]
(Bos taurus)
phospho-p-T774-PKN1 [cytosol]
(Caenorhabditis elegans)
phospho-p-T774-PKN1 [cytosol]
(Canis familiaris)
phospho-p-T774-PKN1 [cytosol]
(Danio rerio)
phospho-p-T774-PKN1 [cytosol]
(Dictyostelium discoideum)
phospho-p-T774-PKN1 [cytosol]
(Drosophila melanogaster)
phospho-p-T774-PKN1 [cytosol]
(Mus musculus)
phospho-p-T774-PKN1 [cytosol]
(Rattus norvegicus)
phospho-p-T774-PKN1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T774-PKN1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T774-PKN1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at 774
Coordinate
774
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_002732.3
,
NP_998725.1
ZINC - World Drugs
PKN1_HUMAN
Guide to Pharmacology - Targets
1520
OpenTargets
ENSG00000123143
ZINC - FDA approved
PKN1_HUMAN
ZINC - Substances
PKN1_HUMAN
ZINC - Biogenic
PKN1_HUMAN
ZINC target
Q16512
PRO
Q16512
PDB
2RMK
,
4OTD
,
4OTG
,
4OTI
,
1CXZ
,
4OTH
,
1URF
,
4NKG
ZINC - Investigational
PKN1_HUMAN
ZINC - Metabolites
PKN1_HUMAN
HPA
ENSG00000123143-PKN1
GeneCards
Q16512
Ensembl
ENST00000242783
,
ENSP00000242783
,
ENST00000342216
,
ENSP00000343325
,
ENSG00000123143
Pharos - Targets
Q16512
ZINC - Predictions - Purchasable
PKN1_HUMAN
HMDB Protein
HMDBP01531
Interactors (75)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NSC5 HOMER3
1
HOMER3 [cytosol]
(R-HSA-6794236)
0.781
7
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:Q01850 CDR2
0.718
6
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:Q8WTV1 THAP3
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q8N108-16 MIER1
0.556
3
UniProt:O76013-2 KRT36
0.556
3
UniProt:Q96QF0-7 RAB3IP
0.556
3
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.556
3
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.556
3
UniProt:Q9P0T4 ZN581
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
IntAct:EBI-22616457 CCSB ORF ID
0.556
3
UniProt:Q5TA45 CPSF3L
1
CPSF3L [nucleoplasm]
(R-HSA-6807411)
0.556
3
UniProt:Q96CS2 HAUS1
1
HAUS1 [cytosol]
(R-HSA-8855199)
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:P08779 KRT16
1
KRT16 [cytosol]
(R-HSA-201581)
0.556
3
UniProt:Q96R06 SPAG5
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:Q96M89-2 CCDC138
0.556
3
UniProt:Q8WU43 CB015
0.556
3
UniProt:Q9BV99 LRC61
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
UniProt:Q8IWV8-2 Q8IWV82
0.556
3
UniProt:Q8TF47 ZFP90
1
ZFP90 [nucleoplasm]
(R-HSA-974988)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9H7B4 SMYD3
1
SMYD3 [nucleoplasm]
(R-HSA-5637688)
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q86T90 K1328
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q6PJH3 Q6PJH3
0.556
3
UniProt:Q8N5Z5 KCD17
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q8IYX8-2 CEP57L1
0.556
3
UniProt:Q8WWB3 DYDC1
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:Q86XR8-3 CEP57
0.556
3
UniProt:P54257 HAP1
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q8IV13 CCNJL
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
5
UniProt:P15289 ARSA
9
ARSA(19-444) [extracellular region]
(R-HSA-6806192)
ARSA(448-507) [extracellular region]
(R-HSA-6806249)
ARSA(19-444) [azurophil granule lumen]
(R-HSA-6798776)
ARSA(448-507) [azurophil granule lumen]
(R-HSA-6798775)
ARSA(448-507) [lysosomal lumen]
(R-HSA-1606798)
OxA-ARSA(19-444) [lysosomal lumen]
(R-HSA-508497)
OxA-ARSA(19-444) [endoplasmic reticulum lumen]
(R-HSA-1614359)
ARSA(19-444) [endoplasmic reticulum lumen]
(R-HSA-1614334)
ARSA(448-507) [endoplasmic reticulum lumen]
(R-HSA-1614307)
0.556
3
UniProt:Q9Y2D8 ADIP
0.556
3
UniProt:Q06547-2 GABPB1
1
NRF2 beta-2 subunit [nucleoplasm]
(R-HSA-1592200)
0.556
3
UniProt:Q9NZ72 STMN3
0.556
3
UniProt:O00303 EIF3F
1
EIF3F [cytosol]
(R-HSA-72540)
0.556
3
IntAct:EBI-16435328 CCSB ORF ID
0.556
3
UniProt:O76014 KRT37
1
KRT37 [cytosol]
(R-HSA-6809614)
0.556
3
UniProt:Q9BZW7 TSG10
0.556
3
UniProt:Q8IW40 CC103
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:P19012 KRT15
1
KRT15 [cytosol]
(R-HSA-6809589)
0.556
3
UniProt:Q9UJW9 SRTD3
0.556
3
UniProt:P08727 KRT19
1
KRT19 [cytosol]
(R-HSA-6809617)
0.556
3
UniProt:P28070 PSMB4
4
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4 [nucleoplasm]
(R-HSA-174343)
PSMB4 [cytosol]
(R-HSA-68750)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:P26641 EEF1G
3
EEF1G [cytosol]
(R-HSA-156925)
EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710839)
EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710850)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:A1L190 SYCE3
1
SYCE3 [nucleoplasm]
(R-HSA-8867779)
0.556
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.556
3
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q15834 CC85B
0.508
2
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