Reactome | TRIM5 [cytosol]

TRIM5 [cytosol]

Stable Identifier

R-HSA-5624342

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tripartite motif-containing protein 5 ecNumber6.3.2.-/ecNumber, TRIM5_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9C035 TRIM5

Gene Names

TRIM5, RNF88

Chain

initiator methionine:, chain:2-493

Reference Genes

BioGPS Gene:85363 TRIM5

COSMIC (genes):TRIM5 TRIM5

CTD Gene:85363 TRIM5

dbSNP Gene:85363 TRIM5

ENSEMBL:ENSG00000132256 TRIM5

HGNC:16276 TRIM5

KEGG:hsa:85363 TRIM5

Monarch:85363 TRIM5

NCBI Gene:85363 TRIM5

OMIM:608487 TRIM5

UCSC:Q9C035 TRIM5

Reference Transcript

Participates

as a member of

IFNG induced TRIMs [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005253241.1, XP_011518729.1, NP_149084.2, NP_149083.2, NP_149023.2, XP_005253240.1

ENSEMBL

ENST00000380027, ENST00000396847, ENSP00000380058, ENSG00000132256, ENST00000684655, ENSP00000393052, ENSP00000369373, ENST00000433961, ENSP00000369366, ENSP00000507420, ENST00000380034

OpenTargets

ENSG00000132256

GeneCards

TRIM5

HPA

ENSG00000132256-TRIM5

PRO

Q9C035

Pharos - Targets

Q9C035

HMDB Protein

HMDBP09321

PDB

2YRG, 2ECV

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.547	3

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