Anterograde trains travel along the axoneme of the cilium at an estimated rate of 2 micrometers per second in an ATP- and kinesin-2-dependent fashion (reviewed in Cole and Snell, 2009). Although the particulars of IFT train-cargo interactions have not been fully elaborated, recent studies in C. reinhardtii and human cells have shown that the IFT B components IFT74 and IFT81 have tubulin-binding sites, while IFT46 is required for the ciliary transport of the outer dynein arm, and more recently, TTC26 has been shown to be required for the transport of motility-related proteins into the flagella (Bhogaraju et al, 2013; Ahmed et al, 2008; Hou et al, 2007; Ishikawa et al, 2014; reviewed in Bhogarju et al, 2014).
Witman, GB, Hou, Y, Pazour, GJ, Follit, JA, Qin, H, Rosenbaum, JL
Snell, WJ, Cole, DG
Weber, K, Mizuno, N, Fort, C, Bhogaraju, S, Blisnick, T, Nigg, EA, Lamla, S, Bastin, P, Taschner, M, Lorentzen, E, Cajanek, L
Mitchell, DR, Lucker, BF, Gao, C, Ahmed, NT, Cole, DG
Stainier, DY, Ide, T, Jiang, X, Ishikawa, H, Marshall, WF, Qin, H, Kamiya, R, Wemmer, KA, Yagi, T, Sasaki, H, Hirono, M, Yanagisawa, H
Weber, K, Bhogaraju, S, Lechtreck, KF, Engel, BD, Lorentzen, E
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