Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ATXN3 [cytosol]
Stable Identifier
R-HSA-5625607
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ataxin-3, ATX3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
ATXN3 binds polyUb-PARK2 (Homo sapiens)
ATXN3 [cytosol] (Homo sapiens)
ATXN3:polyUb-PARK2 [cytosol] (Homo sapiens)
ATXN3 [cytosol] (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
ATXN3 [cytosol] (Homo sapiens)
ATXN3:PARK2 [cytosol] (Homo sapiens)
ATXN3 [cytosol] (Homo sapiens)
ATXN3:polyUb-PARK2 [cytosol] (Homo sapiens)
ATXN3 [cytosol] (Homo sapiens)
ATXN3 family cleave Ub chains (Homo sapiens)
ATXN3,ATXN3L,JOSD1,JOSD2 [cytosol] (Homo sapiens)
ATXN3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54252 ATXN3
Gene Names
ATXN3, ATX3, MJD, MJD1, SCA3
Chain
chain:1-361
Reference Genes
BioGPS Gene:4287 ATXN3
COSMIC (genes):ATXN3 ATXN3
CTD Gene:4287 ATXN3
dbSNP Gene:4287 ATXN3
ENSEMBL:ENSG00000066427 ATXN3
ENSEMBL_homo_sapiens_GENE:ENSG00000066427.25 ATXN3
HGNC:7106 ATXN3
KEGG Gene (Homo sapiens):4287 ATXN3
Monarch:4287 ATXN3
NCBI Gene:4287 ATXN3
OMIM:607047 ATXN3
UCSC:P54252 ATXN3
Reference Transcript
RefSeq:NM_001164780.1 ATXN3
RefSeq:NM_030660.4 ATXN3
RefSeq:NM_001127696.1 ATXN3
RefSeq:NM_004993.5 ATXN3
Other Identifiers
11726361_a_at
11726362_a_at
11726363_x_at
16796020
205415_PM_s_at
205415_s_at
205416_PM_s_at
205416_s_at
235240_PM_at
235240_at
238723_PM_at
238723_at
3576888
3576890
3576891
3576892
3576893
3576894
3576895
3576896
3576897
3576898
3576899
3576903
3576904
3576909
3576910
3576911
3576912
3576914
3576915
3576920
3576923
3576926
3576928
3576929
3576933
36819_at
4287
56787_at
7980940
82526_at
A_23_P129031
A_24_P13595
A_33_P3275310
A_33_P3320762
GE59310
GO:0000226
GO:0003824
GO:0004843
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005764
GO:0005765
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006281
GO:0006289
GO:0006508
GO:0006511
GO:0006515
GO:0007010
GO:0007155
GO:0007268
GO:0007399
GO:0008233
GO:0008234
GO:0010810
GO:0016020
GO:0016363
GO:0016579
GO:0016787
GO:0023052
GO:0030036
GO:0030163
GO:0031625
GO:0031966
GO:0034198
GO:0034605
GO:0035520
GO:0035640
GO:0036211
GO:0042405
GO:0042802
GO:0043161
GO:0043226
GO:0045104
GO:0045202
GO:0048856
GO:0051117
GO:0061578
GO:0070536
GO:0071108
GO:0071218
GO:0140096
GO:1904262
GO:1904294
GO:1904327
GO:1990380
GO:2000060
HMNXSV003021826
Hs.142043.0.A1_3p_at
Hs.46648.0.A1_3p_at
Hs.66521.0.S1_3p_a_at
ILMN_1725696
ILMN_2393497
PH_hs_0025115
TC14002125.hg
g13518018_3p_a_at
Participates
as a member of
ATXN3,ATXN3L,JOSD1,JOSD2 [cytosol] (Homo sapiens)
as an input of
ATXN3 binds polyUb-PARK2 (Homo sapiens)
as a component of
ATXN3:PARK2 [cytosol] (Homo sapiens)
ATXN3:polyUb-PARK2 [cytosol] (Homo sapiens)
Other forms of this molecule
ATXN3 [nucleoplasm]
Inferred To
ATXN3 [cytosol]
(Bos taurus)
ATXN3 [cytosol]
(Canis familiaris)
ATXN3 [cytosol]
(Gallus gallus)
ATXN3 [cytosol]
(Plasmodium falciparum)
ATXN3 [cytosol]
(Sus scrofa)
Atxn3 [cytosol]
(Mus musculus)
Atxn3 [cytosol]
(Rattus norvegicus)
atx-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001121168.1
,
NP_004984.2
,
NP_109376.1
,
NP_001158252.1
OpenTargets
ENSG00000066427
GeneCards
P54252
HPA
ENSG00000066427-ATXN3
Ensembl
ENSP00000339110
,
ENST00000644486
,
ENST00000340660
,
ENSP00000496695
,
ENSG00000066427
,
ENST00000503767
,
ENST00000532032
,
ENSP00000425322
,
ENST00000502250
,
ENSP00000426697
,
ENSP00000437157
PRO
P54252
Pharos - Targets
P54252
Orphanet
15339
PDB
4YS9
,
2AGA
,
1YZB
,
2JRI
,
2DOS
,
2KLZ
,
4WTH
Interactors (106)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.675
4
UniProt:Q01844 EWS
0.666
4
UniProt:Q9BSU1 PHAF1
0.666
4
UniProt:Q14CB8 ARHGAP19
1
ARHGAP19 [cytosol]
(R-HSA-200767)
0.666
4
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.666
9
UniProt:Q8IUI8 CRLF3
0.556
3
UniProt:Q9UHY8 FEZ2
0.556
6
UniProt:P50570-2 DNM2
0.556
3
UniProt:Q8TBK5 Q8TBK5
0.556
9
UniProt:O75330-3 HMMR
0.556
3
UniProt:Q8TB36 GDAP1
2
GDAP1 [peroxisomal membrane]
(R-HSA-9603788)
GDAP1 [cytosol]
(R-HSA-9603796)
0.556
3
UniProt:Q8N895 ZN366
0.556
3
UniProt:P29466-3 CASP1
0.556
9
UniProt:Q9P1A6-3 DLGAP2
0.556
3
UniProt:Q96DC9-2 Q96DC92
0.556
9
UniProt:Q3B7T1 EDRF1
0.556
3
UniProt:Q9H4I2-2 ZHX3
0.556
3
UniProt:Q9Y483-4 MTF2
0.556
3
UniProt:Q8IYF3-3 TEX11
0.556
6
UniProt:Q9H8Y8 GORASP2
2
GORASP2 [Golgi membrane]
(R-HSA-2422385)
p-T222,T225-GORASP2 [Golgi membrane]
(R-HSA-2422965)
0.556
3
UniProt:Q9H8H3 TMT1A
2
METTL7A [extracellular region]
(R-HSA-6800468)
METTL7A [tertiary granule lumen]
(R-HSA-6800170)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9Y458 TBX22
0.556
3
UniProt:Q9HBE1-4 PATZ1
0.556
3
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.556
3
UniProt:Q96G97-4 BSCL2
0.556
3
UniProt:Q6PCB6 ABHD17C
1
ABHD17C [plasma membrane]
(R-HSA-9647774)
0.556
3
UniProt:Q9H7C9 AAMDC
0.556
3
UniProt:Q8N5Z7 Q8N5Z7
0.556
6
UniProt:Q9NS23-4 RASSF1
0.556
3
UniProt:Q6ZNA4-2 Q6ZNA42
0.556
6
UniProt:Q8NEZ2 VPS37A
1
VPS37A [endosome membrane]
(R-HSA-184333)
0.556
3
UniProt:Q9NQ40 SLC52A3
1
SLC52A3 [plasma membrane]
(R-HSA-3165247)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:Q8TDW5-2 SYTL5
0.556
3
UniProt:Q16740 CLPP
1
CLPP [mitochondrial matrix]
(R-HSA-9838002)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.556
3
UniProt:Q96DC9 OTUB2
2
OTUB2 [cytosol]
(R-HSA-933410)
OTUB2 [nucleoplasm]
(R-HSA-6783260)
0.556
9
UniProt:O95551 TDP2
1
TDP2 [nucleoplasm]
(R-HSA-5687253)
0.556
3
UniProt:Q9NRP7 STK36
0.556
3
UniProt:O43488 AKR7A2
1
AKR7A2 [cytosol]
(R-HSA-5423681)
0.556
3
UniProt:P06241-3 FYN
0.556
3
UniProt:Q99932-2 SPAG8
0.556
6
UniProt:Q13064 MKRN3
0.556
3
UniProt:P42574 CASP3
5
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.556
9
UniProt:O94851 MICA2
0.556
3
UniProt:Q9Y2M5 KLHL20
1
KLHL20 [cytosol]
(R-HSA-976032)
0.556
3
UniProt:A4FUJ8 A4FUJ8
0.556
3
UniProt:Q8NA77 TEX19
0.556
3
IntAct:EBI-25958427 CCSB
0.556
9
UniProt:Q3SYB3 FX4L6
0.556
3
IntAct:EBI-25974350 CCSB
0.556
3
UniProt:Q15554-4 Q155544
0.556
3
UniProt:Q9UDY8-2 MALT1
0.556
3
IntAct:EBI-25866689 CCSB
0.556
3
UniProt:Q8IVP1 Q8IVP1
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
6
UniProt:Q02930-3 CREB5
0.556
3
UniProt:Q01844-3 EWSR1
0.556
9
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.556
3
UniProt:Q6UWD8 CP054
0.556
3
UniProt:Q9Y4R8 TELO2
0.556
3
UniProt:Q01844-4 EWSR1
0.556
3
UniProt:Q96FT7-4 ASIC4
0.556
3
UniProt:O95416 SOX14
0.556
3
UniProt:Q9UPM6 LHX6
0.556
3
UniProt:Q8IUW3 SPA2L
0.556
3
UniProt:Q66K80 RUAS1
0.556
3
UniProt:Q8N865 SMIP4
0.556
3
UniProt:Q96LX7-5 CCDC17
0.556
3
UniProt:O15530-4 PDPK1
0.556
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
IntAct:EBI-25973200 CCSB
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
IntAct:EBI-25831191 CCSB
0.556
3
UniProt:Q9Y575-3 ASB3
0.556
3
UniProt:Q03405-2 PLAUR
0.556
3
UniProt:Q15007-2 WTAP
0.556
3
UniProt:Q9BWI9 Q9BWI9
0.556
6
UniProt:P13051-2 UNG
0.556
3
UniProt:Q8NFH3 NUP43
2
NUP43 [nuclear envelope]
(R-HSA-157739)
NUP43 [cytosol]
(R-HSA-376243)
0.556
3
UniProt:Q5VV42 CDKAL1
1
CDKAL1 [endoplasmic reticulum membrane]
(R-HSA-6786612)
0.556
3
UniProt:P06276 BCHE
2
BCHE [extracellular region]
(R-HSA-434469)
BCHE [plasma membrane]
(R-HSA-3640835)
0.556
3
UniProt:Q9H816 DCLRE1B
1
DCLRE1B [nucleoplasm]
(R-HSA-6785735)
0.556
3
UniProt:O75409 HYPM
0.556
3
UniProt:Q15466 NR0B2
1
NR0B2 [nucleoplasm]
(R-HSA-376312)
0.556
3
UniProt:P23142-4 FBLN1
0.556
3
UniProt:Q93062-3 RBPMS
0.556
3
UniProt:Q969S8 HDAC10
1
HDAC10 [nucleoplasm]
(R-HSA-351579)
0.556
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:Q8WY64 MYLIP
1
MYLIP [cytosol]
(R-HSA-8850908)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
9
UniProt:P51665 PSMD7
5
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [cytosol]
(R-HSA-68806)
0.556
9
UniProt:Q9H0M0 WWP1
1
WWP1 [cytosol]
(R-HSA-976037)
0.556
3
UniProt:P22692 IGFBP4
5
IGFBP4 [extracellular region]
(R-HSA-381421)
IGFBP4(157-237) [extracellular region]
(R-HSA-381510)
IGFBP4(22-156) [extracellular region]
(R-HSA-381516)
IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8956754)
p-IGFBP4 [endoplasmic reticulum lumen]
(R-HSA-8957038)
0.556
3
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.556
3
UniProt:Q9BXR5 TLR10
1
TLR10 [plasma membrane]
(R-HSA-167926)
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:Q92995 USP13
2
USP13 [nucleoplasm]
(R-HSA-6781924)
USP13 [cytosol]
(R-HSA-6781893)
0.556
3
UniProt:Q9NVD7 PARVA
1
PARVA [cytosol]
(R-HSA-432848)
0.556
9
UniProt:Q96NC0 ZMAT2
1
ZMAT2 [nucleoplasm]
(R-HSA-9770248)
0.556
3
UniProt:Q8N3R9 MPP5
2
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9689606)
MPP5 [plasma membrane]
(R-HSA-419969)
0.556
3
UniProt:P16581 SELE
1
SELE [plasma membrane]
(R-HSA-2870223)
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:Q16891 IMMT
1
IMMT (MIC60) [mitochondrial inner membrane]
(R-HSA-8949569)
0.463
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text