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SOX17 [nucleoplasm]
Stable Identifier
R-HSA-5625834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor SOX-17, SOX17_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Lineage of Pancreatic Acinar Cells (Homo sapiens)
Definitive endoderm cell produces dorsal foregut endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
dorsal foregut endoderm cell (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Definitive endoderm cell produces ventral foregut endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Dorsal foregut endoderm cell produces duodeno-pancreatic endoderm cell (Homo sapiens)
dorsal foregut endoderm cell (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Duodeno-pancreatic endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Specification of primordial germ cells (Homo sapiens)
Expression of CBFA2T2 in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:CBFA2T2 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of CXCR4 in primordial germ cells (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:CXCR4 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of NANOG in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:NANOG gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of NANOS3 in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of PDPN in primordial germ cells (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:PDPN gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of POU5F1 (OCT4) in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:POU5F1 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of PRDM1 in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:PRDM1 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of SOX17 in primordial germ cells (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of TET2 in primordial germ cells (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TET2 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of TFAP2C in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:TFAP2C gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 and TFAP2C bind the CBFA2T2 gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:CBFA2T2 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 and TFAP2C bind the NANOG gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:NANOG gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 and TFAP2C bind the POU5F1 (OCT4) gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:POU5F1 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 and TFAP2C bind the PRDM1 gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:PRDM1 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 and TFAP2C bind the TFAP2C gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:TFAP2C gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 binds the CXCR4 gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:CXCR4 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 binds the PDPN gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:PDPN gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17 binds the TET2 gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TET2 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
Beta-catenin binds SOX proteins (Homo sapiens)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
TCF:Beta-catenin binds SOX proteins (Homo sapiens)
SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H6I2 SOX17
Gene Names
SOX17
Chain
chain:1-414
Reference Genes
BioGPS Gene:64321 SOX17
COSMIC (genes):SOX17 SOX17
CTD Gene:64321 SOX17
dbSNP Gene:64321 SOX17
ENSEMBL:ENSG00000164736 SOX17
HGNC:18122 SOX17
KEGG:hsa:64321 SOX17
Monarch:64321 SOX17
NCBI Gene:64321 SOX17
OMIM:610928 SOX17
UCSC:Q9H6I2 SOX17
Reference Transcript
RefSeq:NM_022454.3 SOX17
Other Identifiers
11743872_a_at
11743873_x_at
11743874_a_at
17068972
219993_PM_at
219993_at
230943_PM_at
230943_at
3098550
3098551
3098552
3098554
3098555
3098556
3098557
3098558
3098559
3098560
55547_at
61415_at
63045_at
64321
8146462
A_14_P202396
A_23_P82775
A_24_P46946
GE63173
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001525
GO:0001570
GO:0001656
GO:0001706
GO:0001714
GO:0001828
GO:0001947
GO:0003142
GO:0003143
GO:0003151
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0006355
GO:0006357
GO:0007283
GO:0007369
GO:0007492
GO:0007493
GO:0007507
GO:0008013
GO:0010467
GO:0010628
GO:0016055
GO:0021903
GO:0022414
GO:0023019
GO:0030154
GO:0030178
GO:0030308
GO:0031648
GO:0035050
GO:0035987
GO:0042074
GO:0043226
GO:0043565
GO:0045595
GO:0045732
GO:0045893
GO:0045944
GO:0045995
GO:0048568
GO:0048617
GO:0048856
GO:0048863
GO:0048866
GO:0048870
GO:0050821
GO:0060214
GO:0060913
GO:0060914
GO:0060956
GO:0061009
GO:0061010
GO:0061031
GO:0061629
GO:0072091
GO:0072189
GO:0090090
GO:0140110
GO:1903226
GO:1990830
GO:2000035
GO:2000043
GO:2000738
HMNXSV003033224
Hs.98367.0.A1_3p_at
ILMN_1671092
PH_hs_0022233
TC08000376.hg
g11967990_3p_at
Participates
as a component of
SOX17:TFAP2C:PRDM1 gene [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
SOX17:PDPN gene [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:POU5F1 gene [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:TFAP2C gene [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:CBFA2T2 gene [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:NANOG gene [nucleoplasm] (Homo sapiens)
SOX17:CXCR4 gene [nucleoplasm] (Homo sapiens)
SOX17:TET2 gene [nucleoplasm] (Homo sapiens)
as an input of
SOX17 and TFAP2C bind the PRDM1 gene (Homo sapiens)
SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)
SOX17 binds the PDPN gene (Homo sapiens)
SOX17 and TFAP2C bind the POU5F1 (OCT4) gene (Homo sapiens)
SOX17 and TFAP2C bind the TFAP2C gene (Homo sapiens)
SOX17 and TFAP2C bind the CBFA2T2 gene (Homo sapiens)
SOX17 and TFAP2C bind the NANOG gene (Homo sapiens)
SOX17 binds the CXCR4 gene (Homo sapiens)
SOX17 binds the TET2 gene (Homo sapiens)
as an output of
Expression of SOX17 in definitive endoderm (Homo sapiens)
Expression of SOX17 in primordial germ cells (Homo sapiens)
as a member of
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
as a protein marker of
definitive endoderm cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
dorsal foregut endoderm cell (Homo sapiens)
This entity regulates
Positively
Expression of E-cadherin (CDH1) in definitive endoderm
(Homo sapiens)
Inferred To
Homologues of SOX17 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SOX17 [nucleoplasm]
(Drosophila melanogaster)
sox-4 [nucleoplasm]
(Caenorhabditis elegans)
Sox14 [nucleoplasm]
(Drosophila melanogaster)
sox17 [nucleoplasm]
(Danio rerio)
SoxN [nucleoplasm]
(Drosophila melanogaster)
D [nucleoplasm]
(Drosophila melanogaster)
sox-2 [nucleoplasm]
(Caenorhabditis elegans)
sox-3 [nucleoplasm]
(Caenorhabditis elegans)
Sox21b [nucleoplasm]
(Drosophila melanogaster)
sem-2 [nucleoplasm]
(Caenorhabditis elegans)
Sox21a [nucleoplasm]
(Drosophila melanogaster)
ROX1 [nucleoplasm]
(Saccharomyces cerevisiae)
Sox17 [nucleoplasm]
(Mus musculus)
Sox17 [nucleoplasm]
(Rattus norvegicus)
sox17a [nucleoplasm]
(Xenopus tropicalis)
mat1-Mc [nucleoplasm]
(Schizosaccharomyces pombe)
SOX17 [nucleoplasm]
(Bos taurus)
SOX17 [nucleoplasm]
(Canis familiaris)
SOX17 [nucleoplasm]
(Gallus gallus)
SOX17 [nucleoplasm]
(Sus scrofa)
Sox15 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_071899.1
ENSEMBL
ENSP00000297316
OpenTargets
ENSG00000164736
HPA
ENSG00000164736-SOX17
PRO
Q9H6I2
Pharos - Targets
Q9H6I2
Orphanet
SOX17
PDB
4A3N
,
2YUL
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.499
2
UniProt:Q12857 NFIA
1
NFIA [nucleoplasm]
(R-HSA-60134)
0.471
2
UniProt:O00712 NFIB
1
NFIB [nucleoplasm]
(R-HSA-60136)
0.471
2
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