Reactome | IQGAP1 [cytosol]

IQGAP1 [cytosol]

Stable Identifier

R-HSA-5626371

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:P46940 IQGAP1

Gene Names

IQGAP1, KIAA0051

Chain

initiator methionine:, chain:2-1657

Reference Genes

BioGPS Gene:8826 IQGAP1

COSMIC (genes):IQGAP1 IQGAP1

CTD Gene:8826 IQGAP1

dbSNP Gene:8826 IQGAP1

ENSEMBL:ENSG00000140575 IQGAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000140575.13 IQGAP1

HGNC:6110 IQGAP1

KEGG Gene (Homo sapiens):8826 IQGAP1

Monarch:8826 IQGAP1

NCBI Gene:8826 IQGAP1

OMIM:603379 IQGAP1

UCSC:P46940 IQGAP1

Reference Transcript

RefSeq:NM_003870.3 IQGAP1

Other Identifiers

11716765_s_at

11716766_a_at

11716767_at

11752003_a_at

16804804

1825_at

200791_PM_s_at

200791_s_at

210840_PM_s_at

210840_s_at

213446_PM_s_at

213446_s_at

3608114

3608115

3608117

3608129

3608130

3608133

3608136

3608138

3608139

3608140

3608141

3608142

3608143

3608145

3608148

3608151

3608154

3608156

3608157

3608159

3608162

3608164

3608165

3608167

3608170

3608171

3608173

3608176

3608177

3608179

3608181

3608183

3608185

3608186

3608188

3608190

3608192

3608196

3608199

3608200

3608201

3608202

7986010

8826

A_14_P113294

A_24_P321919

A_33_P3417745

D29640_s_at

GE57721

GO:0000278

GO:0000910

GO:0001726

GO:0001817

GO:0005078

GO:0005095

GO:0005096

GO:0005509

GO:0005515

GO:0005516

GO:0005547

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0005938

GO:0007010

GO:0007165

GO:0007173

GO:0007346

GO:0008092

GO:0008289

GO:0008543

GO:0009898

GO:0010761

GO:0015629

GO:0015630

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0016477

GO:0019901

GO:0019903

GO:0019904

GO:0023052

GO:0030154

GO:0030424

GO:0030426

GO:0030496

GO:0030667

GO:0030864

GO:0031252

GO:0031267

GO:0031410

GO:0035305

GO:0036057

GO:0036120

GO:0036211

GO:0036464

GO:0043005

GO:0043087

GO:0043226

GO:0043410

GO:0043539

GO:0044344

GO:0044548

GO:0045296

GO:0045860

GO:0048008

GO:0048856

GO:0048870

GO:0051015

GO:0060090

GO:0070062

GO:0071277

GO:0071364

GO:0072015

GO:0098772

GO:0120025

GO:1903479

GO:1990138

GO:1990904

HMNXSV003003016

HMNXSV003057031

Hs.1742.2.A1_3p_a_at

ILMN_1803819

L33075_at

PH_hs_0000238

TC15000864.hg

g4506786_3p_a_at

g473930_3p_a_at

Participates

as a component of

IQGAP1 dimer [cytosol] (Homo sapiens)

as a candidate of

RAF/MAPK scaffolds [cytosol] (Homo sapiens)

Other forms of this molecule

IQGAP1 [secretory granule membrane]

IQGAP1 [plasma membrane]

Inferred To

IQG1 [cytosol] (Saccharomyces cerevisiae)

rng2 [cytosol] (Schizosaccharomyces pombe)

IQGAP3 [cytosol] (Gallus gallus)

Iqgap1 [cytosol] (Mus musculus)

Iqgap1 [cytosol] (Rattus norvegicus)

pes-7 [cytosol] (Caenorhabditis elegans)

gapA [cytosol] (Dictyostelium discoideum)

Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)

Homologues of IQGAP1 [cytosol] (Schizosaccharomyces pombe)

iqgap1 [cytosol] (Xenopus tropicalis)

rgaA [cytosol] (Dictyostelium discoideum)

IQGAP1 [cytosol] (Bos taurus)

IQGAP1 [cytosol] (Danio rerio)

IQGAP1 [cytosol] (Schizosaccharomyces pombe)

IQGAP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003861.1

OpenTargets

ENSG00000140575

GeneCards

P46940

HPA

ENSG00000140575-IQGAP1

Ensembl

ENSG00000140575, ENST00000268182, ENSP00000268182

PRO

P46940

Pharos - Targets

P46940

HMDB Protein

HMDBP08471

PDB

1X0H, 2RR8, 5L0O, 3I6X, 3FAY

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630)	0.957	19
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.923	12
UniProt:P62999	6	RAC1 [ficolin-1-rich granule membrane] (R-CFA-6804802-2) RAC1 [secretory granule membrane] (R-CFA-6804770-2) RAC1 [endoplasmic reticulum membrane] (R-CFA-5672076-2) GGC-PalmC-RAC1 [plasma membrane] (R-CFA-2316446-2) RAC1 [cytosol] (R-CFA-442615-2) RAC1 [plasma membrane] (R-CFA-351141-2)	0.774	5
UniProt:P25025 CXCR2	2	CXCR2 [secretory granule membrane] (R-HSA-6804771) CXCR2 [plasma membrane] (R-HSA-373796)	0.685	12
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.643	4
UniProt:P0DP25 CALM			0.638	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.626	4
UniProt:O60331-4 PIP5K1C			0.61	7
UniProt:O43707 ACTN4	3	ACTN4 [cytosol] (R-HSA-390558) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729)	0.602	4
UniProt:O08808	4	Diaph1 [ficolin-1-rich granule membrane] (R-MMU-6801388) Diaph1 [plasma membrane] (R-MMU-6801557) Diaph1 [secretory granule membrane] (R-MMU-6801368) Diaph1 [cytosol] (R-MMU-5665970)	0.602	8
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.602	5
UniProt:Q00005 2ABB			0.597	3
UniProt:P63256 ACTG			0.582	3
UniProt:P60706	4	ACTB [nucleoplasm] (R-GGA-3321990) ACTB [cytosol] (R-GGA-201861) ACTB [lysosomal membrane] (R-GGA-196160) ACTB [plasma membrane] (R-GGA-196016)	0.582	3
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.581	5
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.576	4
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:A8MW99 MEI4			0.556	3
UniProt:P32243-2 OTX2			0.556	3
UniProt:P52954 LBX1			0.556	3
UniProt:Q12905 ILF2	5	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [cytosol] (R-HSA-9836392)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.544	4
UniProt:Q96NT1 NP1L5			0.527	2
UniProt:P60660-2 MYL6			0.527	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.527	2
UniProt:Q9NVD7 PARVA	1	PARVA [cytosol] (R-HSA-432848)	0.527	2
UniProt:P08590 MYL3	1	MYL3 [cytosol] (R-HSA-390524)	0.527	2
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.527	3
UniProt:P14649 MYL6B	2	MYL6B [cytosol] (R-HSA-445776) p-S20-MYL6B [cytosol] (R-HSA-445763)	0.527	2
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	3
UniProt:Q9BUA6 MYL10	2	MYL10 [cytosol] (R-HSA-390726) p-S,T-MYL10 [cytosol] (R-HSA-390733)	0.527	2
UniProt:Q8TEL6 TRPC4AP	1	TRPC4AP [plasma membrane] (R-HSA-3211767)	0.527	3
UniProt:O95749 GGPS1	1	GGPS1 [cytosol] (R-HSA-191415)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q96QZ7 MAGI1			0.518	4
UniProt:Q9NP85 NPHS2	1	NPHS2 [plasma membrane] (R-HSA-373633)	0.518	4
UniProt:O00592 PODXL			0.518	4
UniProt:O60500 NPHS1	2	p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (R-HSA-373636) NPHS1 [plasma membrane] (R-HSA-8981500)	0.518	5
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.518	4
UniProt:Q05823 RNASEL	2	RNASEL [mitochondrial matrix] (R-HSA-5223312) RNASEL [cytosol] (R-HSA-1015684)	0.499	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.491	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.463	3
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.462	2