Reactome | GOPC [plasma membrane]

GOPC [plasma membrane]

Stable Identifier

R-HSA-5626572

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Golgi-associated PDZ and coiled-coil motif-containing protein, PIST, CAL, FIG

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases regulate CFTR trafficking (Homo sapiens)
        
        RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)
        
        RHOQ:GTP:GOPC:CFTR [plasma membrane] (Homo sapiens)
        
        GOPC:CFTR [plasma membrane] (Homo sapiens)
        
        GOPC dimer [plasma membrane] (Homo sapiens)
        
        GOPC [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HD26 GOPC

Gene Names

GOPC, CAL, FIG

Chain

initiator methionine:, chain:2-462

Reference Genes

COSMIC (genes):GOPC GOPC

dbSNP Gene:57120 GOPC

ENSEMBL:ENSG00000047932 GOPC

Participates

as a component of

GOPC dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

GOPC [lysosomal membrane]

GOPC [Golgi-associated vesicle membrane]

Inferred To

gopc [plasma membrane] (Danio rerio)

GOPC [plasma membrane] (Bos taurus)

GOPC [plasma membrane] (Canis familiaris)

GOPC [plasma membrane] (Gallus gallus)

GOPC [plasma membrane] (Sus scrofa)

Gopc [plasma membrane] (Mus musculus)

Gopc [plasma membrane] (Rattus norvegicus)

gopc-1 [plasma membrane] (Caenorhabditis elegans)

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.767	10
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.666	4
UniProt:Q8IZQ8 MYOCD	1	MYOCD [nucleoplasm] (R-HSA-9735431)	0.666	4
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:Q15746 MYLK	2	MYLK(1-1914) [cytosol] (R-HSA-445807) p-S1208,S1759-MYLK(1-1914) [cytosol] (R-HSA-5668975)	0.556	3
UniProt:Q99497 PARK7	7	PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) PARK7 [nucleoplasm] (R-HSA-3900141) monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351)	0.556	3
UniProt:Q6UWP7 LCLAT1	1	LCLAT1 [endoplasmic reticulum membrane] (R-HSA-1498783)	0.556	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.556	3

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