Reactome | IQCB1 [cytosol]

IQCB1 [cytosol]

Stable Identifier

R-HSA-5626648

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NPHP5

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        IQCB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15051 IQCB1

Gene Names

IQCB1, KIAA0036, NPHP5, OK/SW-cl.85

Chain

chain:1-598

Reference Genes

BioGPS Gene:9657 IQCB1

COSMIC (genes):IQCB1 IQCB1

CTD Gene:9657 IQCB1

dbSNP Gene:9657 IQCB1

ENSEMBL:ENSG00000173226 IQCB1

ENSEMBL:ENSG00000173226.17 IQCB1

HGNC:28949 IQCB1

KEGG Gene (Homo sapiens):9657 IQCB1

Monarch:9657 IQCB1

NCBI Gene:9657 IQCB1

OMIM:609237 IQCB1

UCSC:Q15051 IQCB1

Reference Transcript

Other Identifiers

11753994_a_at

16958044

205995_PM_x_at

205995_x_at

211707_PM_s_at

211707_s_at

2691799

2691800

2691801

2691802

2691805

2691809

2691811

2691812

2691814

2691817

2691819

2691821

2691827

2691828

2691833

2691835

2691836

2691840

2691841

32657_at

53342_at

8089954

9657

A_23_P84140

D25278_at

GE57125

GO:0001750

GO:0005515

GO:0005516

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0015630

GO:0019899

GO:0030030

GO:0030154

GO:0032391

GO:0043226

GO:0044782

GO:0045171

GO:0045494

GO:0048496

GO:0048856

GO:0060271

GO:0070062

GO:0072686

HMNXSV003001213

HMNXSV003023086

ILMN_1657818

ILMN_2316104

PH_hs_0025445

TC03001699.hg

g13543280_3p_s_at

g7661875_3p_a_at

Participates

as a component of

Inferred To

IQCB1 [cytosol] (Bos taurus)

IQCB1 [cytosol] (Canis familiaris)

IQCB1 [cytosol] (Gallus gallus)

IQCB1 [cytosol] (Sus scrofa)

Iqcb1 [cytosol] (Mus musculus)

Iqcb1 [cytosol] (Rattus norvegicus)

nlgn3 [cytosol] (Xenopus tropicalis)

zgc:101792 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001018865.2, NP_001306036.1, NP_001018864.2

OpenTargets

ENSG00000173226

HPA

ENSG00000173226-IQCB1

GeneCards

Q15051

Ensembl

ENST00000349820, ENSP00000377261, ENST00000310864, ENST00000393650, ENSG00000173226, ENSP00000311505, ENSP00000323756

PRO

Q15051

Pharos - Targets

Q15051

Orphanet

16265

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.638	3
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.633	8
UniProt:Q8TAM2 TTC8	1	TTC8 [cytosol] (R-HSA-5617600)	0.571	5
UniProt:Q8NFJ9 BBS1	1	BBS1 [cytosol] (R-HSA-5617640)	0.571	4
UniProt:Q8N3I7 BBS5	1	BBS5 [cytosol] (R-HSA-5617633)	0.571	8
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.571	5
UniProt:Q3SYG4 BBS9	1	BBS9 [cytosol] (R-HSA-5617630)	0.571	5
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.518	5
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.508	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	2